Hamostaseologie 1996; 16(01): 56-59
DOI: 10.1055/s-0038-1656639
Übersichtsarbeiten/Review Articles
Schattauer GmbH

Heparin and proteoglycans as anti-inflammatory drugs

D. J. Tyrrell
1   Glycomed Inc., Alameda, CA, USA
,
C. P. Page
2   Sackler Institute of Pulmonary Pharmacology, King's College School of Medicine & Dentistry, London
› Author Affiliations
Further Information

Publication History

Publication Date:
26 June 2018 (online)

Summary

Evidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

 
  • REFERENCES

  • 1 Tyrrell D, Kilfeather S, Page CP. Trends Pharm Sci 1995; 16: 198-204
  • 2 Carr J. et al. Thromb Res 1979; 16: 507
  • 3 Sasaki M, Paul W, Douglas GJ, Page CP. Br J Pharmacol 1991; 104: 444P
  • 4 Needham L, Hellewell PG, Williams TW, Gordon JL. Lab Invest 1988; 59: 538-43
  • 5 Bowler SD, Smith SM, Lavercombe PS. Am Rev Resp Dis 1993; 147: 160-3
  • 6 Ahmed T. et al. J Appl Physiol 1993; 74: 1492-8
  • 7 Howell RE, Woeppel SL. Pulm Pharmacol 1993; 6: 237-9
  • 8 Preuss JM, H, Page CP. Am J Hosp Crit Care Med. 1995. (in Press)
  • 9 Motojima S, Frigas E, Loegering DA, Gleich GJ. Am Rev Resp Dis 1989; 139: 801-5
  • 10 Ihrcke NS, Wrenshall LE, Lindaman BJ, Platt JC. Immunol Today 1993; 14: 500-5
  • 11 Bazzoni G. et al. J Lab Clin Med 1993; 121: 268-75
  • 12 Cerletti C, Rajtar G, Marchi E, de Gaetano G. Sem Thromb Hemost 1994; 20: 245-53
  • 13 Arfors K-E, Ley K. J Lab Clin Med 1993; 121: 210-2
  • 14 Tanaka Y, Adams DH, Shaw S. Immunol Today 1993; 14: 111-5
  • 15 Rot A. Immunol Today 1992; 13: 291-4
  • 16 Nelson RM. et al. Blood 1993; 82: 3253-8
  • 17 Tangelder GJ, Arfors K-E. Blood 1991; 77: 1565-71
  • 18 Ley K, Cerrito M, Arfors KE. Am J Physiol 1991; 260: 1667-73
  • 19 Silvestro L. et al. Sem Thromb Haemost 1994; 20: 254-8
  • 20 Springer TA. Cell 1994; 76: 301-14
  • 21 Ager A. Trends Cell Biol 1994; 4: 326-33
  • 22 Carlos TM, Harlan JM. Blood 1994; 84: 2068-101
  • 23 Fezi T. Curr Opin Struct Biol 1993; 3: 701-10
  • 24 Skinner MP. et al. Biol Chem 1991; 266: 5371-4
  • 25 Norgard-Sumnicht KE, Varki NM, Varki A. Science 1993; 261: 480-3
  • 26 Fransson L. In: Heparin. Lone DA, Lindahl U. (eds). Boca Raton, FL: CRC Press; 1989: 115-133
  • 27 Yoshida T, Toyama-Sorimachi N, Miyasaka M, Lee YC. Biochem Biophys Res Commun 1994; 204: 969-74
  • 28 Bargatze RF, Kurk S, Butcher EC, Jutila MA. J Exp Med 1994; 180: 1785-92
  • 29 Yayon A. et al. Cell 1991; 64: 841-8
  • 30 Lindahl U, Lidholt K, Spillmam D, Kjellan L. Thromb Res 1994; 75: 1-32
  • 31 Witt DP, Lander AD. Curr Biol 1994; 4: 394-400
  • 32 Texeira MM, Hellewell PG. Br J Pharmacol 1993; 110: 1496-500
  • 33 Sasaki M, Herd CM, Page CP. Br J Pharmacol 1993; 110: 107-12
  • 34 Metzger WJ, Atkinson L, Henriksen R, Fisher RJ. Allergy Clin Immunol 1992; 89: 235A
  • 35 Seeds EAM, Hanss J, Page CP. J Lipid Mediators 1993; 7: 269-78
  • 340a Seeds EA, M, Home AP, Tyrrell DJ, Page CP. Pulm Pharmacol 1996 (in press).
  • 36 Chihara J, Nakajima S. In: Eosinophils in asthma. . Morley J, Colditz I. (eds). London: Academic Press; 1989: 151-156
  • 37 Kameyoshi Y. et al. J Exp Med 1992; 110: 1496-500
  • 38 Stuckey JA, St Charles R, Edwards BF. Proteins 1992; 14: 277-87
  • 39 Ahmed T. et al. J Appl Physiol 1994; 76: 893-901
  • 40 Dolowitz DA, Dougherty TF. Ann Allergy 1965; 23: 309-13
  • 41 Dahl SV. Z Tuberk 1962; 118: 255-62
  • 42 O'Donnell WJ. et al. Am Rev Resp Dis 1992; 145: A422 (Abstract)
  • 43 Ahmed T, Garrigo J, Danta I. N Engl J Med 1993; 329: 90-5
  • 44 Diamant Z. et al. Am J Hosp Crit Care Med (in press).
  • 45 Antczak M, Kuna P. J Allergy Clin Immunol 1995; 95: 984
  • 46 Crimi N, Armato F, Lamicela M. et al. Eur Resp J 1995; 8: 105
  • 47 Gaffney PR. et al. Am J Gastroenterology 1995; 90: 220-3
  • 48 Ingber A, Trattner A, Cohen IR, Mekori YA. Acta Derm Venerol 1994; 74: 454-6
  • 49 Ross R. Nature 1993; 801-9
  • 50 Ebina M, Takahashi T, Chiba R, Motomiya M. Am Rev Resp Dis 1993; 148: 6720-6
  • 51 Karnovsky MJ, Edelman ER. In: Airways and Vascular remodelling in asthma and cardiovascular disease-Implications for therapeutic interactions. Black J, Page CP. (eds). London:: Academic Press; 1994: 45-69
  • 52 Benitz WE. et al. Am J Respir Cell Mol Biol 1990; 2: 13-24
  • 53 Graham MF. et al. Gastroenterology 1987; 93: 801-9
  • 54 Kilfeather SA. et al. Br J Pharmacol 1995; 114: 1442-6
  • 55 Castellot JJ, Hoover RL, Harper PA, Karnovsky MJ. Am J Pathol 1985; 120: 427-35
  • 56 San Antonio JD, Lander AD, Wright TC, Karnovsky MJ. J Cell Physiol 1992; 150: 8-16
  • 57 Hoover RL, Rosenberg RD, Haering WA, Karnovsky MJ. Circ Res 1980; 47: 578-83
  • 58 Clowes AW, Karnovsky MJ. Nature 1977; 265: 625-6
  • 59 Castellot JJ, Beeler DL, Rosenberg RD, Karnovsky MJ. J Cell Physiol 1984; 120: 315-20
  • 60 Wright TC. et al. J Biol Clin 1989; 264: 1534-42
  • 61 Pukaci LC. et al. Cell Regul 1990; 1: 435-43
  • 62 Green WF, Konnoris K, Woolcock AJ. Am J Respir Cell Mol Biol 1993; 8: 518-21
  • 63 Page CP. Lancet 1991; 337: 717-20