Thromb Haemost 1958; 02(03/04): 269-278
DOI: 10.1055/s-0038-1656278
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Effect of Fibrinogen Concentration on Susceptibility of Clots to in vitro Clot Lysis with Plasmin

A. H Freiman*
1   Clotting Mechanism Section of the Division of Metabolism and Enzyme Studies, Sloan-Kettering Institute, New York, New York
,
E. E Cliffton**
1   Clotting Mechanism Section of the Division of Metabolism and Enzyme Studies, Sloan-Kettering Institute, New York, New York
› Author Affiliations

This research was supported by a research grant No. C—2009 from the National Cancer Institute of the National Institute of Health.
Further Information

Publication History

Publication Date:
07 June 2018 (online)

Preview

Summary

The effect of fibrinogen(fibrin) concentration on the degree of clot lysis has been is shown. These experiments demonstrate: (1) A direct correlation between degree of clot lysis and liberation of radioactive breakdown products, (2) that increasing concentrations of fibrinogen result in decreasing lysis of the clot by a standard fibrinolysin solution, (3) that lysis occurs more rapidly at pH 7.4 than at pH 7.6 and 7.8, (4) that increase in surface area results in increased lysis and (5) that increasing concentration of plasmin results in increased lysis of the clot.

* Research Fellow, Sloan Kettering Institute.


** Associate Professor of Clinical Surgery, Cornell Univ. and Associate, Sloan Kettering, Institute.