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Thromb Haemost 1965; 13(01): 235-243
DOI: 10.1055/s-0038-1656227
Originalarbeiten — Original Articles — Travaux Originaux
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Spontaneous Hemorrhage Precipitated by an Emotional Stress Drug in Anticoagulant-Treated Rats[*]

O. N Lucas
1   Department of Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Canada
,
L. B Jaques
1   Department of Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Canada
› Author Affiliations
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

L.S.D. was used as an emotional stress agent in rats in an attempt to evaluate the influence of the central nervous system in triggering spontaneous hemorrhage in rats treated with anticoagulants. L.A. was used to evaluate whether the hemorrhagic activity of L.S.D. was through the pituitary-adrenal axis. A high percentage of spontaneous hemorrhage was found when the emotional stress agent was combined with the anticoagulant. There was no mortality or hemorrhagic manifestation with anticoagulant alone or in the groups where the treatments were given alone as a control.

* Assisted by the Cardeza Foundation, Jefferson Medical College and Hospital, Philadelphia, Pennsylvania and by the United States Public Health Service Research Grant HE-04877. We are indebted to Dr. A. J. Erslev and Dr. L. B. Kazal of Cardeza Foundation for their interest and support.


 

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