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Hamostaseologie 1993; 13(02): 90-95
DOI: 10.1055/s-0038-1655217
DOI: 10.1055/s-0038-1655217
Originalarbeiten/Original Articles
Signifikante Hemmung der sekundären, ADP-induzierten Plättchenaggregation durch Fischkonsum
Further Information
Publication History
Publication Date:
26 June 2018 (online)
Zusammenfassung
Die Wirkung von n3-Fettsäuren auf die Blutgerinnung ist weiterhin in der Diskussion. In der vorliegenden Arbeit wird die Wirkung des Austausches von 100 g Fleisch gegen 100 g Makrele, im Rahmen einer Kost, die den Empfehlungen der Europäischen Atherosklerosegesellschaft zur alimentären Prävention der koronaren Herzkrankheit entspricht, auf die Thrombozytenaggregation und auf ausgewählte Parameter der plasmatischen Gerinnung untersucht. 14 gesunde Frauen im Alter von 21 bis 26 Jahren nahmen an dem Diätversuch mit zwei je 18tägigen Versuchsperioden mit kontrollierter isokalorischer Kost und Cross-over teil. Die Versuchskost mit Makrele enthielt pro Person 1,7 g Eicosapentaensäure (EPA)/d und 1,9 g Docosahexaensäure (DHA)/d. Fischkonsum bewirkte bei der sekundären, ADP-induzierten Plättchenaggregation eine signifikante Hemmung (p ≤0,05). Die Thrombozytenzahl sank in der Versuchsgruppe signifikant um bis zu 26% des Ausgangswertes.
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LITERATUR
- 1 Ahmed AA, Holub BJ. Alteration and recovery of bleeding times, platelet aggregation, and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod liveroil. Lipids 1984; 19: 617-24.
- 2 American Heart Association, Committee on Nutrition. Diet and coronary heart disease. Circulation 1978; 58: 62.
- 3 Balleisen L, Baily J, Epping PH, Schulte H, van de Loo J. Epidemiological study on factor VII, factor VIII, and fibrinogen in an industrial population. Thromb Haemostas 1985; 54: 475-9.
- 4 Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic west-coast Eskimos. Lancet 1971; 01: 1143-6.
- 5 Bang HO, Dyerberg J. Plasma lipids and lipoproteins in Greenlandic west-coast Eskimos. Acta Med Scand 1972; 192: 85-94.
- 6 Begemann H, Rastetter J. Klinische Hämatologie. Stuttgart: Thieme; 1986
- 7 Blache D, Bouthillier D, Davignon J. Acute influence of smoking on platelet behaviour, endothelium and plasma lipids and normalisation by aspirin. Atherosclerosis 1992; 93: 179-88.
- 8 Bonaa Kh, Bjerve KS, Lanier AP, Nordoy A. Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Trom0 Study. Am J Clin Nutr 1992; 55: 1126-34.
- 9 Born GVR. Aggregation of the blood platelets by adenosin diphosphate and its reversal. Nature 1962; 194: 927-9.
- 10 Breddin HK. Prostaglandine und Plättchenfunktion. Stuttgart: Schattauer; 1978
- 11 Brosche T, Platt D, Summa J-D. Die Erythrozytenmembran als Indikator des Ernährungsverhaltens. Med Welt 1992; 43: 15-9.
- 12 Cabre E, Periago JL, Mingorance MD, Fernandes-Banares F, Abad A, Esteve M, Gil A, Lachica M, Gonzales-Huix F, Gassull MA. Factors related to the plasma fatty acid profile in healthy subjects with special reference to antioxidant micronutrient status: a multivariate analysis. Am J Clin Nutr 1992; 55: 831-7.
- 13 Chierietti SM, Cimminiello C, Rudelli G. Platelet-aggregation inhibiting drugs for prevention of mayor ischemic events. Thromb Res 1990; Suppl XI: 43-7.
- 14 Driss F, Vericel E, Lagarde M, Dechavanne M, Darcet PH. Inhibition of platelet aggregation and thromboxane synthesis after intake of small amounts of eicosapentaenoic acid. Thromb Res 1984; 36: 389-96.
- 15 Dyerberg J, Bang HO. Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet 1979; 02: 433-5.
- 16 Dyerberg J, Bang HO, Stofferson E. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet 1978; 01: 117-9.
- 17 Eritsland J, Seljeflot I, Arnesen H, Abdelnoor M. Longterm effects of fish oil supplementation in patients with coronary artery disease: influence on lipoproteins, coagulation and fibrinolysis. Thromb Res 1992; 65: 75.
- 18 European Atherosclerosis Society, Study Group. Strategies for the prevention of coronary heart disease: A policy statement of the European Atherosclerosis Society. Eur Heart J 1987; 08: 77-88.
- 19 Goodnight SH, Harris WS, Connor WE. The effects of dietary n-3 fatty acids on platelet composition and function in men: a prospective controlled study. Blood 1981; 58: 880-5.
- 20 Gümbel L. Veränderungen des Arachidonsäureund Docosahexaensäurespiegels im Serum unter Koronar-Diät mit Makrele bei ischämischen Herzerkrankungen. FIMA Schriftenreihe 1988; 16: 116-26.
- 21 Hamsten A, De Faire UD, Walldius G. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 1987; 02: 3-8.
- 22 Hay CRM, Durber AP, Saynor R. Effect of fish oil on platelet kinetics in patients with heart disease. Lancet 1982; 01: 1269-72.
- 23 Herold PS, Kinsella JE. Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. Am J Clin Nutr 1986; 43: 566-98.
- 24 Knapp HR, Reilly JAG, Alessandrini P, Fitzgerald GA. In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. N Engl J Med 1986; 314: 937-42.
- 25 Kromhout D, Bosschieter EB, LezenneCoulander de C. Fish consumption and 20year mortality from coronary heart disease. N Engl J Med 1986; 312: 1205-9.
- 26 Krzywanek HJ. Klinische Bedeutung der Thrombozytendiagnostik unter besonderer Berücksichtigung der spontanen und induzierten Aggregation. Stuttgart: Fischer; 1987
- 27 Lands WEM. Fish and Human Health. Orlando (USA): Academic; 1986
- 28 Lorenz R, Spengler U, Fischer S, Duhm J, Weber PCW. Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation 1983; 67: 504-11.
- 29 Lowe GDO, Wood DA, Douglas JT, Riemersma RA, Macintyre CCA, Takase T, Tuddenham EGD, Forbes CD, Elton RA, Oliver MF. Relationships of plasma viscosity, coagulation and fibrinolysis to coronary risk factors and angina. Thromb Haemostas 1991; 65: 339-43.
- 30 Maderna P, Colli S, Eligini S, Mussoni L, Mainardi G, Galli C, Sirtori CR, Stragliotto E, Tremoli E. Changes in haemostatic variables following administration of an EPA and DHA enriched preparation. Thromb Res 1992; 65: 76.
- 31 Miller GJ, Martin JC, Webster J, Wilkes H, Miller NE, Wilkinson WH, Meade TW. Association between dietary fat intake and plasma factor VII coagulant activity a predictor of cardiovascular mortality. Atherosclerosis 1986; 60: 269-77.
- 32 Meade TW, Brozovic M, Mellows S, Miller GJ, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imson JD, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 02: 533-7.
- 33 Mitropoulos KA, Miller GJ, Reeves BEA, Wilkes HC, Cruickshank JK. Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in middle-aged mem. Atherosclerosis 1989; 76: 203-8.
- 34 National Instituts of Health Consensus Development. Conference Statement: Lowering blood cholesterol to prevent heart disease. J Am Med Assoc 1985; 253: 2080-6.
- 35 O’Brien JR. Platelet aggregation, Part II: Some results from a new method of study. J Clin Pathol 1962; 15: 452.
- 36 Ragni MV, Miller BJ, Whalen R, Miller BJ, Ptachcinski R. Bleeding tendency, platelet function and pharmacokinetics of Ibuprofen and Zidovudine in HIV (+) hemophilic men. Am J Haematol 1992; 40: 176-82.
- 37 Salonen JT, Salonen R, Penttilä I, Herrassen J, Jauhiainen M, Kantola M, Lappeteläinen R, Mäenpää Ph, Alftnan G, Puska P. Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease. Am J Cardiol 1985; 56: 226-31.
- 38 Schacky von C, Siees W, Lorenz R, Weber PC. Ungesättigte Fettsäuren, Eicosanoide und Arteriosklerose. Internist 1984; 25: 268-74.
- 39 Scharf RE. Thrombozyten und Mikrozirkulationsstörungen. Stuttgart: Schattauer; 1986
- 40 Shekelle RB, Macmillan AShryock, Paul O, Lepper M, Stamler J, Lin S, Raynor WJ. Diet, serum cholesterol, and death from coronary heart disease: The Western Electric Study. N Engl J Med 1981; 304: 65-70.
- 41 Simopoulos AP, Kifer RR, Martin RE. Health effects of polyunsaturated fatty acids in seafoods. Orlando (USA): Academic; 1986
- 42 Simopoulos AP. Letter to the editor. N Engl J Med 1987; 316: 627.
- 43 Sinclair H. Eskimos diets and disease. Lancet 1983; 01: 1139.
- 44 Singer P. Zur diätetischen Wertigkeit von EPA im Vergleich zu anderen mehrfach ungesättigten Fettsäuren. Z Klin Med 1986; 41: 2099-101.
- 45 Stephan H. Thrombozytenaggregationshemmung zur Rezidivprophylaxe zerebraler Ischämien. Med Welt 1992; 31: 559-61.
- 46 Thorngren M, Shafi M, Born GVR. Delay in primary haemostasis produced by a fish diet without change in local thromboxan A2 . Br J Haematol 1984; 58: 567-78.
- 47 Weiss H. Platelets and ischaemic heart disease. N Engl J Med 1980; 302: 225-6.
- 48 Wilhelmsen I, Svärsudd K, Korsan-Bengtsen LB, Welin L, Tibblin GC. Fibrinogen as a risk factor for stroke and myocardial , infarction. N Engl J Med 1984; 311: 501-5.
- 49 Willis AL. Nutritional and pharmacological factors in eicosanoid biology. Nutrition Rev 1981; Vol 39 (08) 289-301.
- 50 Yarnell JWG, Elwood PC, Renaud S. Platelet function and ischaemic heart disease in the Caerphilly Study, preliminary results. Basel: Bibliotheca Nutritio et Dieta 1987; (40) 19-27.