Serum Thrombotic Accelerator (STA) Deficiency in the Newborn

Summary

Serum thrombotic accelerator (STA) activity was shown to be definitely decreased in the blood of a group of newborn infants. Both newborn serum and BaS04 eluates of serum dialyzed against saline were devoid of clot promoting activity when the in vivo STA assay of Wessler was used. However, serum eluates dialyzed against distilled water showed good STA activity; therefore, an inhibitor, removed by water dialysis, was suggested to be present in newborn serum.

• References

• 1 Aballi A. J, de Lamerens S. Coagulation changes in the neonatal period and in early infancy. Pediat. Clin. N. Amer. 09: 785 1962;
• 2 Deykin D, Wessler S. Activation product, Factor IX, serum thrombotic accelerator activity, and serum-induced thrombosis. J. clin. Invest. 43: 160 1964;
• 3 Henderson E. S, Bapaport S. I. The thrombotic activity of activation product. J. clin. Invest. 41: 235 1962;
• 4 Hilgartner M. W, Smith G. H. Plasma thromboplastin antecedent (Factor XI) levels in the neonate. J. Pediat. 66: 747 1965;
• 5 Howell B. M, Scott G. B. D. The role of lipoproteins in the production of hypercoagulability: a new concept. Brit. J. exp. Path. 45: 618 1964;
• 6 Kurkcuoglu M, McElfresh A. E. The Hageman factor: Determination of its concentration in the neonatal period and presentation of a case of Hageman factor deficiency. J. Pediat. 57: 61 1960;
• 7 Nossel H. L, Lawzkowsky P, Levy S, Mibashan B. S, Hansen J. D. L. A study of coagulation factor levels in women during labor and in their newborn infants. Thrombos. Diathes. haemorrh. (Stuttg) 16: 185 1966;
• 8 Reimer S. M, Thomas D. P. Role of Factors XII, XI, and IX in serum and plasma-induced thrombosis. Amer. J. Physiol. 205: 1265 1963;
• 9 Wessler S, Reimer S. M, Sheps M. G. Biologic assay of a thrombosis-inducing activity in human serum. J. appl. Physiol. 14: 943 1959;