Ultrastructural Observations on Platelet Adhesion Reactions^[*]

Summary

The interaction of platelets with collagen and with other platelets in collageninduced platelet aggregates has been studied with the electron microscope. The contours of aggregated platelets closely conformed to each other at a finite and regular distance, usually 200 to 300 Ångstroms. Structural conformity of platelets and collagen was less regular and occurred with a narrower separation. These findings are discussed in relation to observations of platelet interaction with fibrin and latex particles.

^* Study supported by grant No. HE-05415-06 of the National Heart Institute, National Institutes of Health, United States Public Health Service.

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