Circulating Anticoagulant Against Factor VIII Coexistent with Some Immunological Reactions in a Female

S Lopaciuk; A Naleczynska; H Czaja; I Walewska; S Pawelski

doi:10.1055/s-0038-1654839

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1964; 11(02): 444-451
DOI: 10.1055/s-0038-1654839

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Circulating Anticoagulant Against Factor VIII Coexistent with Some Immunological Reactions in a Female

Authors

S Lopaciuk

¹From Institute of Hematology, Warsaw, Poland
A Naleczynska

¹From Institute of Hematology, Warsaw, Poland
H Czaja

¹From Institute of Hematology, Warsaw, Poland
I Walewska

¹From Institute of Hematology, Warsaw, Poland
S Pawelski

¹From Institute of Hematology, Warsaw, Poland

Abstract

Summary

The authors described a case of acquired hemorrhagic diathesis which appeared in 53-year old female three weeks after pleuropneumonia. The bleeding tendency resulted from a circulating anticoagulant selectively active against factor VIII. Its properties were investigated. The circulating anticoagulant was accompanied by hypergammaglobulinemia, cold agglutinins, and platelet agglutinins active at 4° C. Coombs’ test was positive. Treatment with corticosteroids caused the disappearance of the anticoagulant from the circulation and complete remission of the disease. It seems that the anticoagulant arose by an autoimmune mechanism.

Full Text

References

References
1 Bidwell E. Fibrinolysins of human plasma. Biochem. J. 55: 497 1953;
2 Biggs R, Macfarlane R. G. Human blood coagulation and its disorders. 3rd ed.. Blackwell: Oxford; 1962
3 Breckenridge R. T, Ratnoff O. D. Studies on the nature of the circulating anticoagulant directed against antihemophilic factor: with notes on an assay for antihemophilic factor. Blood 20: 137 1962;
4 Copley A. L, Lalich J. J. Bleeding time, lymph time and clot resistance in men. J. clin. Invest 21: 145 1942;
5 Deutsch E. Acquired inhibitors. Progress in Coagulation. Suppl. 1 ad vol. 7 Thrombos. Dia-thes. haemorrh. (Stuttg.) 1962
6 Egeberg O. Acquired circulating anticoagulant in classical hemophilia. Scand. J. clin. Lab. Invest 13: 535 1961;
7 Hall M. Haemophilia complicated by an acquired circulating anticoagulant: a report of three cases. Brit. J. Haemat. 07: 340 1961;
8 Hartert H. Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klin. Wschr. 26: 577 1948;
9 Hicks N. D, Pitney W. R. A rapid screening test for disorders of thromboplastin generation. Brit. J. Haemat. 03: 227 1957;
10 Hjort P, Rapaport S. I, Owren P. A. A simple, specific one-stage prothrombin assay using Rusell’s viper venom in cephalin suspension. J. Lab. clin. Med. 46: 89 1955;
11 Hougie C. Pseudohaemophilia: an acquired haemorrhagic diathesis due to a circulating anticoagulant. J. clin. Path. 06: 30 1953;
12 Husom O. A one stage method for the assay of platelet factor 3. Scand. J. clin. Lab. Invest 13: 609 1961;
13 Koller F, Loeliger A, Duckert F. Experiments on a new clotting factor (Factor VII). Acta haemat. (Basel) 06: 1 1951;
14 Lee M. L, Raccuglia G. Acquired inhibitor of blood coagulation. Ann. intern. Med. 56: 946 1962;
15 Lee R. I, White P. D. A clinical study of the coagulation time of blood. Amer. J. med. Sci. 145: 495 1913;
16 Lewis J. H, Ferguson J. H, Arends T. Haemorrhagic disease with circulating inhibitors of blood clotting: anti-AHF and anti-PTC in eight cases. Blood 11: 846 1956;
17 Lozner E. L, Jolliffe L. S, Taylor F. H. Hemorrhagic diathesis with prolonged coagulation time associated with a circulating anticoagulant. Amer. J. med. Sci. 199: 318 1940;
18 Margolius A, Jackson D. P, Ratnojf O. D. Circulating anticoagulants: a study of 40 cases and review of the literature. Medicine (Baltimore) 40: 145 1961;
19 Nilsson I. M, Blombäck M, von Francken I. On an inherited autosomal hemorrhagic diathesis with antihemophilic globulin deficiency and prolonged bleeding time. Acta med. scand. 159: 35 1957;
20 Nussey A. M, Dawson D. W. Haemophilia-like disease due to an autoantibody. Brit. med. J. II: 1077 1957;
21 Owren P. A. The coagulation of blood. Investigations on a new clotting factor. Acta med. scand. Suppl. 194 1947;
22 Quick A. J. Hemorrhagic Diseases. Lea and Febiger. Philadelphia. 1957
23 Rees H. M, Ecker E. E. An improved method for counting blood platelets. J. Amer. med. Ass. 80: 621 1923;
24 Sise H. S, Gauthier J, Desforges J, Becker R. Spontaneous circulating anticoagulant (Antifactor VIII). Case report and review of the literature. Amer. J. Med. 32: 964 1962;
25 Waaler B. A. Contact activation in the intrinsic blood clotting system. Scand. J. clin. Lab. Invest Suppl. 37: 1959.
26 Wolf P. A modification for routine laboratory use Stefanini’s method for estimation of factor V in human oxalated plasma. J. clin. Path. 06: 34 1953;