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Thromb Haemost 1964; 11(01): 267-274
DOI: 10.1055/s-0038-1654827
Originalarbeiten — Original Articles — Travaux Originaux
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A Study in Viscosity and Clotting of Blood in Haemophiliacs*

L Dintenfass   **
1   Department of Medicine, University of Sydney, Sydney, Australia
,
P Castaldi   ***
1   Department of Medicine, University of Sydney, Sydney, Australia
› Author AffiliationsSupported by a grant from the National Health and Medical Research Council of Australia and by a grant from the Post-Graduate Medical Foundation.
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

Viscosity and clotting of blood were studied an a series of eight haemophilic (Factor VIII deficiency) patients. A cone-in-cone rotational viscometer was employed. Viscosity was determined over a range of rates of shear (0.04- 100 sec-1). Blood was found to be thixotropic, but great variations were observed between the individual cases. The extreme difference in viscosity between the severe and the mild haemophiliacs was 20-fold.

A tendency was observed for the clotting time to decrease with an increase in the velocity gradient. Clotting time was found also to decrease with an increase in temperature if determined at high rates of shear.

** Formerly Senior Research Officer of the National Health and Medical Research Council; Now Senior Research Fellow of the National Heart Foundation, Department of Medicine, University of Sydney.


*** Formerly Craig Mostyn Research Fellow in Haemophilia; New Research Fellow, Institute de Recherche de la Faculte de Medicine, HKpital St. Louis, Place du Docteur Fourmier, France.


 

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