A Study in Viscosity and Clotting of Blood in Haemophiliacs*

L Dintenfass; P Castaldi

doi:10.1055/s-0038-1654827

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1964; 11(01): 267-274
DOI: 10.1055/s-0038-1654827

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

A Study in Viscosity and Clotting of Blood in Haemophiliacs*

L Dintenfass^**

¹Department of Medicine, University of Sydney, Sydney, Australia

,

P Castaldi^***

¹Department of Medicine, University of Sydney, Sydney, Australia

› Author Affiliations

Abstract

Summary

Viscosity and clotting of blood were studied an a series of eight haemophilic (Factor VIII deficiency) patients. A cone-in-cone rotational viscometer was employed. Viscosity was determined over a range of rates of shear (0.04- 100 sec-¹). Blood was found to be thixotropic, but great variations were observed between the individual cases. The extreme difference in viscosity between the severe and the mild haemophiliacs was 20-fold.

A tendency was observed for the clotting time to decrease with an increase in the velocity gradient. Clotting time was found also to decrease with an increase in temperature if determined at high rates of shear.

Full Text

References

References
1 Bell W. N, Alten H. G. A brain extract as a substitute for platelet suspension in the thromboplastin generation test. Nature 174: 880 1954;
2 Biggs R, Macfarlane R. G. Human Blood Coagulation. Blackwell; Oxford: 1962
3 Dintenfass L. Thixotropy of blood and proneness to thrombus formation. Circulât. Res. 11: 233 1962;
4 Dintenfass L. An application of a cone-in-cone viscometer to the study of viscocity, thixotropy and clotting of blood. Biorheology. 01: 91 1963;
5 Dintenfass L. Viscosity and clotting of blood in venous thrombsis and coronary occlusion. Circulât. Res. 14: 1 1964;
6 Dintenfass L. Rheology of blood in cardiovascular diseases. Nature. 199: 813 1963;
7 Hardisty R. M, Macpherson J. C. A one-stage factor VIII (anti-haemophilic globulin) assay and its use in venous and capillary plasma. Thrombos. Diathes. haemorrh. (Stuttg.). 07: 215 1962;
8 Macfarlane R. G. Haemophilia and related conditions. Postgrad, med. J. 30: 72 1954;
9 Margolis J. The effect of colliodal silica on blood coagulation. Aust. J. exp. Biol. med. Sci. 39: 249 1961;
10 Rozenberg M, Dintenfass L. Thrombus formation in vitro. Aust. J. exp. Biol. med. Sci. (in print)