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Thromb Haemost 1963; 10(02): 317-331
DOI: 10.1055/s-0038-1654787
Originalarbeiten — Original Article — Travaux Originaux
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Statistical Correlation of Liver Function Tests with Coagulation Factor Deficiencies in Laennec’s Cirrhosis[*]

H. G Kupfer
1   Division of Clinical Pathology, Medical College of Virginia
,
W Gee
2   Medical Service of the Veterans Administration Hospital, Richmond, Va
,
A Timothy Ewald
3   Division of Biometry of the Medical College of Virginia, Richmond, Va
4   General Electric, TEMPO, 735 State Street, Santa Barbara, Calif
,
Malcolm E. Turner
3   Division of Biometry of the Medical College of Virginia, Richmond, Va
5   Department of Biometry, Emory University School of Medicine, Atlanta 22, Ga
› Author Affiliations
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Publication History

Publication Date:
28 August 2018 (online)

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Summary

Hemorrhage is one of the most serious complications of chronic liver disease. Deficiency of plasma coagulation factors, thrombocytopenia, and increased vascular fragility have been reported in many patients with Laennec’s cirrhosis. Factors V, VII, IX, X and prothrombin were deficient in a majority of the 25 patients included in this study.

Six tests of liver function and seven of plasma coagulation factors were evaluated, using the method of statistical regression analysis. The intercorrelation of tests in each group was evaluated as well as the correlation between liver function tests and plasma coagulation factors. Fibrinogen deficiency was not felt to play a significant role in hemorrhagic diathesis in our cases.

* Supported in part by NIH Grant Nr. 5868: 3717


 

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