Inactivation of Antiplasmin and Complement C¹ in Human Plasma Rendered Fibrinolytic by Synthetic Organic Compounds^[*]

Summary

Certain synthetic organic compounds induce upon dissolution marked fibrinolytic activity in human plasma, reduce the antiplasmin titer of human or bovine serum and destroy the complement C¹ of human plasma. Generation of fibrinolytic activity and reduction of antiplasmin are concentration-depending time reactions. Destruction of complement C¹ occurs almost instantaneously. Minor molecular modifications abolish all three activities of the compounds.

^* Read in part at the Eleventh Annual Symposion on Blood, Wayne State University, Detroit 1963. Supported by the American Heart Association and in part by the Wyoming Heart Association.

The valuable advice of Dr. David Pearlman, Division of Immunology, Dept. of Medicine, University of Colorado School of Medicine, for complement titrations is gratefully acknowledged.

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