Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis

E. A Loeliger; B. v. d Esch; C. Ch ter Haar Romeny-Wachter; H. L Booij

doi:10.1055/s-0038-1654496

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1960; 4(02): 196-200
DOI: 10.1055/s-0038-1654496

Originalarbeiten — Original Articles — Travaux Originaux

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Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis^[*]

E. A Loeliger

¹Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland

,

B. v. d Esch

¹Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland

,

C. Ch ter Haar Romeny-Wachter

¹Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland

,

H. L Booij

¹Clinic for Internal Medicine, University Hospital (Director. Prof. Dr. J. Mulder), Leyden, Holland

› Author Affiliations

Abstract

Summary

The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed.

Full Text

References

References
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Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis[*]

Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis^[*]