Defects in and Variability of the Thromboplastic System in Horse Plasma

Summary

Among 35 apparently normal horses, without any sign of hemorrhagic diathesis, which were tested with the thrombin generation test, 11 horses showed defects in the plasma thromboplastic system. The coagulation defects were inconstant and 3 horses showed transition from one thromboplastic defect to another.

This study was supported by a grant to Dr. Tage Astrup from the Josiah Macy Jr. Foundation, New York.

• References

• 1 Astrup T, Müllertz S. The fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. Biophys. 40: 346 1952;
• 2 Astrup T, Sjolin Knud-Erik. Defects in Blood Coagulation. Dan. Med. Bull. 4: 164-168 1957;
• 3 Archer R. K, Flute P. Heparin and Thromboplastin Generation in the Horse. Nature 183: 235-236 1959;
• 4 Bell W. N, Alton H. G. A brain extract as a substitute for platelet suspension in the thromboplastin generation test. Nature 174: 880-881 1954;
• 5 Bell W. N, Archer R. K, Tomlin S. C. Coagulation mechanism of the horse. Nature 175: 596 1955;
• 6 Bell W. N, Tomlin S. C, Archer R. K. The coagulation mechanism of the blood of the horse with particular reference to its “hemophiloid” status. J. Comp. Path, and Therapeut. 65: 255-261 1955;
• 7 Biggs R, Douglas A. S. The thromboplastin generation test. J. clin. Pathology 6: 23-29 1953;
• 8 Biggs R, Macfarlane R. G. Human blood coagulation and its disorders. Oxford: Blackwell; 476 1957
• 9 Bogart R, Muhrer M. E. The inheritance of a hemophilialike condition in swine. J. of Heredity 33: 59-64 1942;
• 10 Brinkhous K. M. A study of the clotting defect in hemophilia: The delayed formation of thrombin. Am. J. Med. Sei. 198: 509-516 1939;
• 11 Brinkhous K. M, Graham J. B. Hemophilia in the female dog. Science 111: 723-724 1950;
• 12 Field R. A, Rickard C. G, Hull F. B. Hemophilia in a family of dogs. Cornell Vet. 36: 285-300 1946;
• 13 Graham J. B, Buckwalter J. A, Hartley L. J, Brinkhous K. M. Canine hemophilia. Observations on the course, the clotting anomaly and the effect of blood transfusions. J. Exp. Med. 90: 97-111 1949;
• 14 Hikmet P. Die Blutplättchen beim gesunden und kranken Pferd, Hund und Schwein. Arch. Wiss. Prakt. Tierheilk. 55: 222-250 1927;
• 15 Hill J. M, Speer R. J. Combined hemophilia and PTC deficiency. Blood 10: 357-361 1955;
• 16 Hogan A. G, Muhrer M. E, Bogart R. A hemophilia-like disease in swine. Proc. Soc. Exp. Biol, and Med. 48: 217-219 1941;
• 17 Marotto R. C, Postiglione F, Jorio S. Antihemophilic activity of bovine and equine plasma. Clin. Therapeutica 9: 3-27 1955;
• 18 Merkins J. Ned. Ind. Bladen v. Diergeneesk. 50: 149 1938; cit. after Field et al.: Cornell Vet. 36: 298 [1946]).
• 19 Miale J. B, Wilson M. P. Studies on the thromboplastin generation test. II. Basic mechanism and theoretical aspects. Am. J. Clin. Path. 26: 984-997 1956;
• 20 Pitney W. R. Mild hemophilia — a clinical and laboratory study. Aust. Ann. Med. 6: 44-52 1957;
• 21 Ramot B, Singer K, Heller P, Zimmerman H. J. Hageman factor deficiency. Blood 11: 745-752 1956;
• 22 Ratnoff O. D. A familial trait characterized by deficiency of a clot-promoting fraction of plasma. J. Lab. Clin. Med. 44: 915-916 1954;
• 23 Ratnoff O. D, Colopy J. E. A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma. J. Clin. Invest. 34: 602-613 1955;
• 24 Ratnoff O. D, Margolius Jr A. Hageman trait: An asymptomatic disorder of blood coagulation. Transact. Ass. Am. Phys. 68: 149 1955;
• 25 Ratnoff O. D, Rosenblum J. M. The role of Hageman factor in the initiation of clotting by glass. J. Lab. Clin. Med. 50: 941-942 1957;
• 26 Sjølin K.-E. The thrombin generation test in the diagnosis of classical hemophilia and Christmas disease. Scand. J. Clin, and Lab. Invest. 8: 138-144 1956; a
• 27 Sjølin K.-E. Deficiency of a factor in the plasma thromboplastin system, revealed by freezing. Dan. Med. Bull. 3: 222-223 1956; b
• 28 Sjølin K.-E. Lack of Christmas factor in horse plasma. Nature 178: 153 1956; c
• 29 Sjølin K.-E. Coagulation defect in horse plasma. Proc. Soc. Exp. Biol. Med. 94: 818-820 1957; a
• 30 Sjølin K.-E. Deficiency of the Hageman factor demonstrated by the thrombin generation test. Thromb. Diath. haem. 1: 153-157 1957; b
• 31 Sjølin K.-E. Variations of the coagulation defects in hemophilia. VII Congresso della Società Internazionale di Ematologia. Rom: 287 1958
• 32 Sjølin K.-E. Personal communication. 1959.
• 33 Soulier J. P, Larrieu M. J. Measurements of thromboplastin factors and profactors in plasma. J. Lab. Clin. Med. 41: 849-864 1953;
• 34 Verstraete M, Vandenbroucke J. The thromboplastin generation test. Some practical modifications and study of the role of factor V and VII on the formation of plasma thromboplastin. Acta Med. Scand. 155: 37-48 1956;