Platelet Count and Thrombelastographic Maximal Amplitude in Experimental Thrombocythemias

Summary

Experimental thrombocythemias were produced in animals by injecting pantetine, serotonin, progesterone, testosterone, STH, and by carrying out orchid-ectomy. Thrombelastographic determinations of the maximal amplitude were carried out under such conditions and the results correlated with the platelet counts. No significant increases of the maximal amplitude could be observed, even in the presence of very high platelet levels, nor the thrombelastographic signs of a platelet impairment could be detected.

 

• References

• 1 Annoni G, Leone M. Primi risultati clinici con la pantetina. Azione piastrino-poietica notevole. Minerva med 1955; 1: 756
• 2 Arlolli O, Ballerini G. La patogenesi delle sindromi emorragiche e trombotiche nelle trombocitemie. Haematol 1957; 42: 1279
• 3 Ballerini G, Cantelli T. Piastrinosi sperimentale da 5-idrossitriptamina. Boll. Soc. Ital. Ematol 1955; 3: 404
• 4 Bigelow F. S. Serotonin activity in blood. Measurements in normal subjects and in patients with thrombocythemia hemorrhagica and other hemorrhagic states. J. Lab. and Clin. Med 1954; 43: 759
• 5 Bonard E. C. Les thrombocythémies hémorragipares. Med. Hyg 1956; 14: 516
• 6 Bruni G, Serra U. Sulla trombocitosi provocata nel ratto da trattamento prolungato con 5-idrossitriptamina. Atti Soc. Lomb. Sc. Med. Biol 1956; 11: 1
• 7 D’Antuono G, Tura S. Trombocitemia emorragica. Boll. Soc. Ital. Ematol 1957; 5: 29
• 8 De Biasi R, Bile C, Manes L. Trombocitemia emorragica essenziale: contributo casistico. Progr. med 1958; 14: 690
• 9 de Nicola P. The laboratory diagnosis of coagulation defects. C. C. Thomas; Springfield, Ill: 1955
• 10 de Nicola P. Thrombelastography. C. C. Thomas; Springfield, Ill: 1957
• 11 de Nicola P. et al L’azione di alcuni ormoni sulla coagulazione del sangue. Arch. Maragliano 1959; 14: 1
• 12 de Nicola P, Mazzetti G. M. Experimenteller und klinischer Beitrag zur Charakterisierung der thrombophilen Zustände. Deutsches Arch. f. klin. Med 1956; 203: 300
• 13 Di Guglielmo G. Le malattie mieloproliferative. Atti Soc. Lomb. Sc. Med. Biol 1956; 11: 330
• 14 Fountain J. R. Haemorrhagic thrombocythemia. Report of two cases treated with radioactive phosphorus. Brit. M. J 1958; 2: 126
• 15 Garattini S, Moriguchi P. La pantetina condiziona un aumento delle piastrine circolanti. Atti Soc. Lomb. Sc. Med. Biol 1954; 9: 150
• 16 Hardisty R. M, Wolff H. H. Haemorrhagic thrombocythaemia: a clinical and laboratory study. Brit. J. Haematol 1955; 1: 390
• 17 Hartert H. Die Thrombelastographie in der Differentialdiagnose der hämorrhagischen Diathesen. Schweiz. med. Wschr 1949; 79: 318
• 18 Hartert H. Die Thrombelastographie. Eine Methode zur physikalischen Analyse des Blutgerinnungsvorganges. Zschr. f. d. ges. exper. Med 1951; 117: 189
• 19 Hartert H. Klinische Blutgerinnungsstudien mit der Thrombelastographie. II. Die Thrombocytopathien. Deutsches Arch. f. d. klin. Med 1952; 199: 293
• 20 Hedinger C, Langemann H. Ausgesprochene Thrombocytose bei Ratten unter Behandlung mit 5-Oxytryptamin. Schweiz. med. Wschr 1955; 85: 368
• 21 Hermann R. E. Thrombocytosis, its occurrence and association with abnormal bleeding, report of a case. Ann. Surg 1957; 145: 238
• 22 Hörder M. H, Pileggi J. Beeinflussung der Haftfähigkeit des Thrombus durch Leukozyten der chronisch leukämischen Myelose. Acta Haematol 1957; 17: 111
• 23 Bong Hak Hyun, Davwon E. A, Custer R. Ph. Evaluation of thrombocythemia by the thromboplastin generation test. Am. J. Clin. Path 1958; 29: 539
• 24 Klein E, Farber S, Freeman G, Florentino R. The effects of varying concentrations of human platelets and their stored derivatives on the recalcification time of plasma. Blood 1956; 11: 910
• 25 Korinth E. Thrombocythaemia bei myeloischer Leukaemia. Ärztl. Forsch 1957; 1: 555
• 26 Kupfer H. G, Ebbels B. J, Miller J. N, Thorna G. W, Russi S. Essential thrombocythemia. Ann. Int. Med 1958; 48: 685
• 27 Lawrence A. M, Contopoulos A. N. Platelet counts in the rat after hypo-physectomy, gonadectomy, or thyroidectomy. Proc. Soc. Exper. Biol. and Med 1958; 98: 738
• 28 Levin W. C, Celander D. R, Guest M. The mechanism of hemorrhagic manifestations associated with thrombocythemia. J. Lab. and Clin. Med 1955; 46: 930
• 29 Mallarmé J. Les thrombocythémies hémorragipares. Haematol 1957; 42: 1193
• 30 Marchai G, Duhamel G, Leroux M. E, Chenderovitch J, Goglin G. Deux cas de Splenomegalie myéloïde avec thrombocythémie hémorragipare: action du myléran: intéret des thrombo-élastogrammes. Sang 1957; 28: 245
• 31 Marchal G, Leroux M. E, Duhamel G. M, Samama M. Aspects thrombo-dynamographiques de l’hyperplaquettose dans les leucémies myeloïdes et dans les thrombocythémies hémorragiques. Sang 1958; 29: 666
• 32 Marchai G, Leroux M. E, Samama M. Les anomalies thrombodynamographi-ques dans les leucémies myeloides. Sang 1958; 29: 265
• 33 Miale J. B, Garrett V. R. Studies on the thromboplastin generation test. III. The effects of dilution, storage, and concentration of platelets. Am. J. Clin. Path 1957; 27: 701
• 34 Ottaviani P. Influenza dei fattori della coagulazione sull’elasticità del coagulo. Progr. med 1959; 15: 83
• 35 Perry S. Coagulation defects in leukemia. J. Lab. and Clin. Med 1957; 50: 229
• 36 Schüpbach A. Thrombosekrankheit bei essentieller (?) Thrombocythämie. Schweiz, med. Wschr 1954; 84: 95
• 37 Spaet T. H. Anticoagulants derived from blood platelets. J. Appl. Physiol 1957; 11: 119
• 38 Spaet T. H, Bauer S, Melamed S. Hemorrhagic thrombocythemia. A blood coagulation disorder. A.M.A. Arch. Int. Med 1956; 98: 377
• 39 Stefanini M, Dameshek W. Hemorrhagic disorders. Grune & Stratton; New York: 1955
• 40 Winckelmann G, Hörder M. H. Veränderungen der Gerinnselfestigkeit durch Leukozyten der myeloischen Reihe. Acta haemat 1957; 18: 261