Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1959; 3(04): 501-509
DOI: 10.1055/s-0038-1654406
DOI: 10.1055/s-0038-1654406
Originalarbeiten — Original Articles — Travaux Originaux
The Effect of Macroglobulins and their Dissociation Units on Release of Platelet Factor 3
Summary
The effect of the macroglobulins on the release of platelet factor 3 has been reviewed (Fig. 3). It has been shown that dissociation units of native macro-globulins fail to exert any deleterious effect upon platelets. Evidence is presented to support the theory that molecular size is of paramount importance in preventing platelet factor 3 release.
MissingLinkText
MissingLinkText
-
References
- 1 Pachter M. R, Johnson S. A, Nebett T. R, Truant J. P. Bleeding, Platelets and Macroglobulinemia. Amer. J. clin. Path 1959; 31: 467-482
- 2 SalmOn J. Etude Immunoélectrophorétique des Antigènes Plaquettaires Humains. Schweiz. med. Wschr 1958; 88: 1047-1049
- 3 Habich H. Zur Antigen-Analyse des Paraproteins bei Makroglobulinämien. Schweiz. med. Wschr 1953; 83: 1253-1257
- 4 Deutsch H. F, Morton J. Human Serum Macroglobulins and Dissociation Units, I. Physicochemical Properties. J. biol. Chem 1958; 231: 1107-1118
- 5 Alkjaersig N, Abe I, Seegers W. H. Purification and Quantitative Determination of Platelet Factor 3. Amer. J. Physiol 1955; 181: 304-308
- 6 Seegers W. H, Smith H. P. Factors which Influence the Activity of Purified Thrombin. Amer. J. Physiol 1942; 137: 348-354
- 7 Murray M, Johnson S. A, Seegers W. H. Relationship of Certain Anti-histaminic Drugs to the Activation of Purified Prothrombin. Amer. J. Physio 1954; 178: 10-16
- 8 JohnsOn S. A, Smathers W. M, Schneider G. L. Platelets and their Plasma Cofactor Activity in the Activation of Purified Prothrombin. Amer. J. Physiol 1952; 170: 631-636
- 9 Deutsch H. F, Morton J. Human Serum Macroglobulins and Dissociation units, II. Immunochemical Properties. J. biol. Chem 1958; 231: 1119-1127
- 10 Langdell R. D, Adelson E, Furth F. W, Crosby W. D. Dextran and Prolonged Bleeding Time. J. Amer. med. Ass 1958; 166: 346-351
- 11 Jacobaeus U. Studies on the Effect of Dextran on the Coagulation of Blood. Acta med. Scand 1957; 332: 1-103
- 12 Isliker H. Zur Chemie der Makroglobuline. Helv. med. Acta 1958; 25: 41-53
Requests for reprints should be addressed to:
M. R. Pachter, M.D.
Dept. of Pathology Memorial Center for Cancer and Allied Diseases
New York
N. Y.
-
References
- 1 Pachter M. R, Johnson S. A, Nebett T. R, Truant J. P. Bleeding, Platelets and Macroglobulinemia. Amer. J. clin. Path 1959; 31: 467-482
- 2 SalmOn J. Etude Immunoélectrophorétique des Antigènes Plaquettaires Humains. Schweiz. med. Wschr 1958; 88: 1047-1049
- 3 Habich H. Zur Antigen-Analyse des Paraproteins bei Makroglobulinämien. Schweiz. med. Wschr 1953; 83: 1253-1257
- 4 Deutsch H. F, Morton J. Human Serum Macroglobulins and Dissociation Units, I. Physicochemical Properties. J. biol. Chem 1958; 231: 1107-1118
- 5 Alkjaersig N, Abe I, Seegers W. H. Purification and Quantitative Determination of Platelet Factor 3. Amer. J. Physiol 1955; 181: 304-308
- 6 Seegers W. H, Smith H. P. Factors which Influence the Activity of Purified Thrombin. Amer. J. Physiol 1942; 137: 348-354
- 7 Murray M, Johnson S. A, Seegers W. H. Relationship of Certain Anti-histaminic Drugs to the Activation of Purified Prothrombin. Amer. J. Physio 1954; 178: 10-16
- 8 JohnsOn S. A, Smathers W. M, Schneider G. L. Platelets and their Plasma Cofactor Activity in the Activation of Purified Prothrombin. Amer. J. Physiol 1952; 170: 631-636
- 9 Deutsch H. F, Morton J. Human Serum Macroglobulins and Dissociation units, II. Immunochemical Properties. J. biol. Chem 1958; 231: 1119-1127
- 10 Langdell R. D, Adelson E, Furth F. W, Crosby W. D. Dextran and Prolonged Bleeding Time. J. Amer. med. Ass 1958; 166: 346-351
- 11 Jacobaeus U. Studies on the Effect of Dextran on the Coagulation of Blood. Acta med. Scand 1957; 332: 1-103
- 12 Isliker H. Zur Chemie der Makroglobuline. Helv. med. Acta 1958; 25: 41-53