Blood Clotting, Plasma Kinins and Fibrinolysis

Summary

In plasma of women on oral contraception a marked activation of factor VII takes place, when stored overnight at low temperatures. This activation is dependent on factor XII, and evidence is presented that it may be mediated by the plasma kinin system.

• References

• 1 Altman R, Hernker H. C. Contact activation in the Extrinsic Blood Clotting System. Thrombos. Diathes. haemorrh. (Stuttg.) 18: 525 1967;
• 2 Armstrong D, Mills G. L, Sicuteri F. Physiological influence on the liberation of human plasma kinin at low temperatures. In: Hypotensive Peptides, Proceedings of the International Symposium, Florence 1965. Springer; New York: 1966
• 3 Fearnley G. R. Fibrinolysis, in: Recent Advances in Blood Coagulation. Poller L. Ed. J.A. Churchill Ltd; London: 1969
• 4 Iatridis S. I, Ferguson J. H. Active Hagemanfactor: A plasma lysokinase of the human fibrinolytic system. J. clin. Invest 41: 1277 1962;
• 5 Jacobsen G. D. Th© caseinolytic method for the determination of plasminogen-plasmin in human plasma and serum. Scand. J. clin. Lab. Invest 16: 372 1964;
• 6 Margolis J. Activation of plasma by contact with glass: Evidence for a common reaction which releases plasma kinin and initiates coagulation. J. Phys 144: 1 1958;
• 7 Ratiioff O. D, Colopy J. E. A familial hemorrhagic trait associated with a deficiency of a clotpromoting fraction of plasma. J. clin. Invest 34: 602 1955;
• 8 Schächter M. Kallikreins and Kinins. Phys. Rev 49: 509 1969;
• 9 Schrogie J. J, Solomon H. M, Zieve Ph.D. Effect of oral contraceptives on vitamin K-dependent clotting activity. Clin, pharm. Ther 08: 670 1967;