Heparinised Clotting Factor Concentrates in Patients with Christmas Disease and Liver Disease

Summary

Evidence has been sought of activation of the coagulation system in two groups of patients following the infusion of two heparinised clotting factor concentrates. No changes were detected in 13 patients with mild hepatic dysfunction. In six studies on patients with Christmas disease induced abnormalities occurred in only one. Activation of the coagulation mechanism did not occur in another individual who had received the same batch of material.

• References

• 1 Cash J. D, Dalton R. G, Middleton S, Smith J. K. 1975; Studies on the thrombogenicity of Scottish factor IX concentrates in dogs. Thrombosis et Diathesis Haemorrhagica (Stuttgart) 33: 632.
• 2 Denson K. W. E, Biggs R. 1972. Laboratory diagnosis, tests of clotting function and their standardisation. In: Biggs R. (ed.): Human Blood Coagulation, Haemostasis and Thrombosis.. Blackwell Scientific Publications; Oxford: 310.
• 3 Dike G. W. R, Bidwell E, Rizza C. R. 1972; The preparation and clinical use of a new concentrate containing factor IX, prothrombin and factor X and of a separate concentrate containing factor VII. British Journal of Haematology 22: 469.
• 4 Ellis B. C, Stransky A. 1961; A quick and accurate method for the determination of fibrinogen in plasma. Journal of Laboratory and Clinical Medicine 58: 477.
• 5 Hedner N, Nilsson I. M, Bergentz S. E. 1976; Various prothrombin complex concentrates and their effect on coagulation and fibrinolysis in vivo . Thrombosis and Haemostasis 35: 386.
• 6 Kasper C. K. 1973; Postoperative thromboses in haemophilia β. New England Journal of Medicine 289: 160.
• 7 Marchesi S. L, Bunney R. 1974; Prothrombincomplex concentrates and thrombosis. New England Journal of Medicine 290: 403.
• 8 Preston F. E, Winfield D. A, Malia R. G, Blackburn E. K. 1975; Serial changes in the coagulation system following clotting factor concentrate infusion. Thrombosis et Diathesis Haemorrhagica (Stuttgart) 34: 475.
• 9 Steinberg M. H, Dreiling B. J. 1974; Vascular lesions in hemophilia β. New England Journal of Medicine 289: 592.