Preventive Effect of Pyridinolcarbamate on Thrombohemorrhagic Phenomenon and Hemorrhagic Necrosis

Summary

Forty two rabbits were injected intravenously with 5 ml/kg of 0.5% agar solution or 100 μg/kg of bacterial endotoxin derived from Escherichia coli. After 1 min 0.1 ml of 500 μg/ml of adrenaline was injected intradermally in abdominal skin of each rabbit. After 24 hrs hemorrhage in adrenaline-injected regions was observed in 28 of 38 regions in abdominal skin of rabbits treated with agar and in 11 of 14 regions of rabbits treated with endotoxin. Both the hemorrhages were similarly reduced with the pretreatment of 40 μg of pyridinolcarbamate given locally with statistical significance (P < 0.01 and 0.05).

• References

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