Adenosine Diphosphate (ADP) Breakdown in Human Plasma with Reference to Platelet Aggregation and Uraemia

I. E. T Gan; B. G Firkin

doi:10.1055/s-0038-1651222

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1968; 19(03/04): 438-450
DOI: 10.1055/s-0038-1651222

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Adenosine Diphosphate (ADP) Breakdown in Human Plasma with Reference to Platelet Aggregation and Uraemia

I. E. T Gan

¹Clinical Research Unit, Royal Prince Alfred Hospital and Department of Medicine, University of Sydney

,

B. G Firkin

¹Clinical Research Unit, Royal Prince Alfred Hospital and Department of Medicine, University of Sydney

› Author Affiliations

Abstract

Summary

1. A correlation between platelet aggregation and the plasma enzyme(s) ability to degrade Adenosine Diphosphate (ADP) has been confirmed.

2. This plasma activity has been shown to be reduced in 6 patients with uraemia in whom platelet aggregation was demonstrably impaired but not in two whose platelet function was normal. The incorporation of ¹⁴C labelled ADP-8-¹⁴C was also only reduced in uraemic patients with abnormal platelet aggregation.

3. These findings are discussed with particular reference to possible implication in mechanism involved in ADP aggregation of platelets.

Full Text

References

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