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Thromb Haemost 1966; 15(03/04): 365-380
DOI: 10.1055/s-0038-1649438
Originalarbeiten — Original Articles — Travaux Originaux
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Effect of Alkaline and Acid Phosphatases on Clotting:

Evidence that Alkaline Phosphatase Enhances Activation of Factor IX by SF, and that Acid Phosphatase Enhances Plasmatic Anti-SF[*]
P. G Iatridis
1   Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, N. G
,
J. H Ferguson
1   Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, N. G
› Author Affiliations
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Publication Date:
27 June 2018 (online)

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Summary

Alkaline phosphatase is found to enhance the activation of factor IX by SF. The correlation of the distribution of alkaline phosphatase in electrophoretic fractions with the clotting tests suggest that the “beta” fraction contains the responsible factor for the acceleratory effect of alkaline phosphatase on clotting.

Acid phosphatase, while not exerting a direct inhibitory effect on SF, does enhance the plasmatic anti-SF activity. The “beta” and “F-gamma” fractions seem to contain the responsible factor of acid phosphatase for the plasmatic anti-SF enhancement.

SF preparation has no acid or alkaline phosphatase activity.

A tentative schema is proposed to explain the effects of acid and alkaline phosphatase on clotting.

* This study was aided by USPHS Research Grant No. HE01510-12.


 

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