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Thromb Haemost 1966; 15(01/02): 231-237
DOI: 10.1055/s-0038-1649424
DOI: 10.1055/s-0038-1649424
Originalarbeiten — Original Articles — Travaux Originaux
Comparative Research on the Fibrinolytic Action of Different Nicotinic Acid Derivatives Following Their Prolonged Administration into Rabbits
Further Information
Publication History
Publication Date:
27 June 2018 (online)
Summary
Six different nicotinic acid derivatives were given intravenously into rabbits for 28 days. The dosage was calculated on the basis of equivalents of nicotinic acid. Fibrinolytic activity in plasma was studied by means of the fibrin plate method (heated plates; euglobulinic precipitate, with and without the addition of activator). Plasmin and plasminogen activities were evaluated. The most significant results concern the differences in duration, intensity and type (plasmin and/or plasminogen increase) of effect of the different nicotinic acid derivatives.
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