The Effect of Adrenaline Infusions and of Muscular Exercise upon the Blood Level of Factor VIII (Antihaemophilic A Factor) in the Rat

Summary

The activity of factor VIII (antihaemophilic A factor) in rat blood does not increase upon adrenaline infusions or short term muscular exercise. A possible increase in the factor VIII activity in blood of rats was observed during a postoperative period, however. Short-lasting Nembutal anaesthesia had no influence on the factor VIII blood level in rats.

• References

• 1 Egeberg O. Changes in the coagulation system following major surgical operations. Acta med. scand 171: 679-685 1962;
• 2 Egeberg O. The effects of exercise on the blood clotting system. Scand. J. clin. Lab. Invest 15: 8-13 1963;
• 3 Egeberg O. On the nature of the blood antihemophilic A factor (AHA = F.VIII) increase associated with muscular exercise. Scand. J. clin. Lab. Invest 15: 202-203 1963;
• 4 Egeberg O. Changes on the activity of antihemophilic A factor (F. VIII) and in the bleeding time associated with muscular exercise and adrenaline infusion. Scand. J. clin. Lab. Invest 15: 539-549 1963;
• 5 Hauge A, Amundsen E, Waaler B. A. Changes in blood proaccelerin (Factor V) in rats with intestinal strangulation obstruction. Thrombos. Diathes. haemorrh. (Stuttg) 12: 49-63 1964;
• 6 Hjort P, Bapaport S. I, Owren P. A. A simple, specific one-stage prothrombin assay using Russel’s viper venom in cephalin suspension. J. Lab. clin. Med 46: 89-97 1955;
• 7 Ingram G. I. G. Increase in antihaemophilic globulin activity following infusion of adrenaline. J. Physiol 156: 217-224 1961;
• 8 Nilsson D, Waaler B. A. Observations on factor VIII (antihaemophilic A factor) stability in rabbit and rat plasma. Thrombos. Diathes. haemorrh. (Stuttg) 14: 374-386.
• 9 Owren P. A. The coagulation of blood. Investigations on a new clotting factor Acta med. scand 128 (suppl. 194) 327pp 1947;
• 10 Rizza C. R. Effect of exercise on the level of antihaemophilic globulin in human blood. J. Physiol 156: 128-135 1961;