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DOI: 10.1055/s-0038-1649127
Effect of Aspirin on the Thrombelastogram of Human Blood
Publication History
Received
04 July 1973
Accepted
14 August 1973
Publication Date:
30 June 2018 (online)
Summary
Thrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.
* Present address: Laboratory for Haemostasis and Thrombosis Research, Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20157 Milano, Italy.
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