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Thromb Haemost 1973; 30(01): 155-159
DOI: 10.1055/s-0038-1649112
DOI: 10.1055/s-0038-1649112
Original Article
Platelet Factor 3 Activity Made Available from Human Platelets by ADP
Inhibition by ColchicineFurther Information
Publication History
Received for publication
09 April 1973
Accepted for publication
23 July 1973
Publication Date:
30 June 2018 (online)
Summary
Pretreament of normal human platelets with colchicine at a final concentration of 10-3 M strikingly modifies their subsequent reaction to ADP. The generation of platelet factor 3 activity is inhibited, the secondary wave of aggregation fails to appear, and platelet factor 4 is not released. Colchicine also inhibits the increase in platelet factor 3 activity that results from washing and centrifugation of platelets.
* Present address : Albert Einstein School of Medicine, Bronx, New York.
** Present address : Medical Department A, Rikshospitalet, Oslo, Norway.
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