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Thromb Haemost 1973; 30(02): 272-279
DOI: 10.1055/s-0038-1649074
DOI: 10.1055/s-0038-1649074
Original Article
Tranexamic Acid in the Control of Spontaneous Bleeding in Severe Haemophilia
Further Information
Publication History
Received for publication
30 March 1973
Accepted for publication
12 June 1973
Publication Date:
30 June 2018 (online)
Summary
A double-blind cross-over study of the prophylactic value of tranexamic acid (“Cyklokapron”), in a dose of 3.0 g per day, against spontaneous bleeding episodes in severe haemophilia was undertaken. Records of bleeding episodes were maintained during therapy in twenty boys with confirmed clinical severity, over two school terms. A significant reduction (p <0.05) in spontaneous bleeding episodes was attained with an associated lessening in the transfusion requirement of therapeutic material, and without obvious side effects. Recommendations are made for further investigations.
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