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Thromb Haemost 1972; 28(01): 129-134
DOI: 10.1055/s-0038-1649048
Original Article
Schattauer GmbH

Coagulation Studies in a Case of Severe Congenital Hypofibrinogenemia

T Barbui
1   Division of Haematology (Director: Prof. E. Dini), Regional Civil Hospital, Vicenza, Italy, and Division of Cardiology (Director: Prof. A. Poppi), Regional Civil Hospital, Verona, Italy
,
P. I Porciello
1   Division of Haematology (Director: Prof. E. Dini), Regional Civil Hospital, Vicenza, Italy, and Division of Cardiology (Director: Prof. A. Poppi), Regional Civil Hospital, Verona, Italy
,
E Dini
1   Division of Haematology (Director: Prof. E. Dini), Regional Civil Hospital, Vicenza, Italy, and Division of Cardiology (Director: Prof. A. Poppi), Regional Civil Hospital, Verona, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
29 June 2018 (online)

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Summary

A case of severe congenital hypofibrinogenemia is presented. The patient was a 26 year old female with congenital heart disease.

Partial thromboplastin time, Quick’s time and thrombin time were infinite. There was no immunoelectrophoretic precipitation with anti-fibrinogen serum. The thrombo-elastogram, carried out in PPP, indicated the complete lack of fibrinogen. On the contrary, the thromboelastographic pattern in PRP showed a very small opening of the branches, suddenly followed by their rejoining. Using an immunodiffusion method, it was possible to estimate the fibrinogen level at 12 mg%.

 

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