Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1973; 29(03): 661-670
DOI: 10.1055/s-0038-1648108
DOI: 10.1055/s-0038-1648108
Original Article
A Simple Indirect Method to Evaluate Platelet
Aggregation The Clot Retraction Inhibition (CRI) TestFurther Information
Publication History
Publication Date:
30 June 2018 (online)
Summary
A simple indirect method to evaluate platelet aggregation is described: the Clot Retraction Inhibition (CRI)-test, based on the observation that clot retraction is inhibited by previous in vitro platelet aggregation ; a highly significant correlation exists between the inhibition of clot retraction and each of the three parameters of aggregation curves which have been evaluated by turbidometry.
The CRI-test is more sensitive in certain circumstances (thrombocytopenia, hyperlipaemia, contamination with red or white cells), than turbidometry.
The CRI-test can also be satisfactorily performed on citrated total blood.
-
References
- 1 Born G. V. R. 1962. Aggregation of blood platelets by adenosine diphosphate and its reversal Nature (London). 194 927.
- 2 Born G. V. R, Cross M. J. 1963; The aggregation of blood platelets. Journal of Physiology 168: 178.
- 3 Breddin’ K. 1965; Über die gesteigerte Thr omb o cy ten - agglutination bei Gefäßkrankheiten. Schweizerische Medizinische Wochenschrift 95: 655.
- 4 Brinkhous KM, Leroy EC, Cornell WP, Brown RC, Hazlehurst JL, Vennart GP. 1958; Microscopic studies of platelet agglutination ; nature of thrombocyte agglutinating activity of plasma. Proceedings of the Society of Experimental Biology and Medicine 98: 379.
- 5 Chandler AB. 1958; In vitro thrombotic coagulation of the blood. A method for producing a thrombus. Laboratory Investigation 07: 110.
- 6 Cronberg S. 1971; A mathematical model for optical platelet aggregation test. Acta Medica Scandinavica, Suppl 525: 49.
- 7 de Gaetano G, Donati MB, Vermylen J, Verstraete M. 1971; Inhibition of clot retraction by previous in vitro platelet aggregation. Thrombosis et Diathesis Haemorrhagiea (Stuttg.) 26: 449.
- 8 de Gaetano G, Yeemylen J, Verstraete M. 1970; Platelet aggregation by a specific human immunoglobulin preparation Thrombosis et Diathesis Haemorrhagica (Stuttg.). 24: 419.
- 9 Lüscher E. F. 1956; Viscous metamorphosis of blood platelets and clot retraction. Vox Sanguinis 01: 133.
- 10 McBride J. A. 1968; Platelet adhesiveness: the effect of centrifugation on the measurement of adhesiveness in platelet - rich plasma. Journal of Clinical Pathology 21: 397.
- 11 O’Brien J. R. 1962; Platelet aggregation. II. Some results from a new method of study. Journal of Clinical Pathology 15: 452.
- 12 O’Brien J. R. 1971; Factors influencing the optical platelet aggregation test. Acta Medica Scandinavica, Suppl 525: 43.
- 13 O’Brien J. R, Heywood J. B, Heady J. A. 1966; The quantitation of platelet aggregation induced by four compounds: a study in relation to myocardial infarction. Thrombosis et Diathesis Haemorrhagica (Stuttg.) 16: 752.
- 14 Vermylen J, de Gaetano G, Verstraete M. 1973. Platelets and thrombosis. In: Poller L. (ed.) Recent Advances in Thrombosis. Churchill; London: 113.