Action of Coagulation Factors on Experimental Thrombogenesis and Their Changes after Thrombosis

G. A Marbet; F Duckert

doi:10.1055/s-0038-1648104

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(03): 619-632
DOI: 10.1055/s-0038-1648104

Original Article

Schattauer GmbH

Action of Coagulation Factors on Experimental Thrombogenesis and Their Changes after Thrombosis

G. A Marbet

¹Department of Internal Medicine First University Medical Clinic, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland

,

F Duckert

¹Department of Internal Medicine First University Medical Clinic, Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland

› Author Affiliations

Abstract

Summary

The action of ellagic acid, serum and acetylsalicylic acid on the frequency of thrombosis has been studied in a modification of the thrombosis model of Blake et al. (1959). Thrombi were formed in the external jugular veins of the rats by irritation with a formalin-methanol solution. The rate of thrombosis is highest with ellagic acid and lowest with acetylsalicylic acid. None of the groups of treated rats differed significantly from the control group. A short activation of coagulation with either ellagic acid or serum does not greatly enhance the thrombosis rate. The action of acetylsalicylic acid in the prophylaxis of thrombosis is not very convincing. Species differences may play a role.

Exhaustive coagulation studies before and after operation showed in each group a specific behaviour of the coagulation factors. There were significant differences between thrombosis positive and thrombosis negative animals. With ellagic acid, however, there was no difference between animals with and without thrombosis.

Full Text

References

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