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Thromb Haemost 1976; 36(03): 525-531
DOI: 10.1055/s-0038-1648072
Original Article
Schattauer GmbH

Effect of the Root Extract of Fagara Zanthoxyloides on Blood Coagulation

E. M Essien
1   Departments of Haematology and Chemistry, University of Ibadan, Ibadan, Nigeria
,
J. I Okogun
1   Departments of Haematology and Chemistry, University of Ibadan, Ibadan, Nigeria
› Author Affiliations
Further Information

Publication History

Received 10 May 1976

Accepted 04 August 1976

Publication Date:
03 July 2018 (online)

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Summary

The clot-promoting activity of the aqueous extract of Fagara zanthoxyloides Lam plant is described for the first time. It significantly shortened the PTT (K) of normal and factor VIII deficient plasma while it manifested no such action on factor IX-deficient plasma. This activity could be demonstrated in the residue of the lyophilized aqueous extract after its successive extraction with ether, chloroform and methanol. It could not be attributed to the purified fractions: Zanthoxylol or its modified form 3, 4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid (DBA), hesperidin, Fagaramide or the ether soluble fraction of the aqueous extract.

 

  • References

  • 1 Calderwood J. M, Fish M. 1966; Screening for tertiary and quartenary alkaloids in some Fagara species. Journal of Pharmacy and Pharmacology 18: 119.
    CrossrefPubMedGoogle Scholar
  • 2 Ekong D. E. U, Okogun J. L, Enyinihi V. U, Balogh-Nair V, Nakanishi K, Natta C. 1975; New antisickling agent 3, 4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid. Nature 258: 743.
    CrossrefPubMedGoogle Scholar
  • 3 El-Said F, Fadulu S. O, Kuye J. O. O, Sofowora E. A. 1971; Native cures in Nigeria. (II) The antimicrobial properties of the buffered extracts of chewing sticks. Lloydia 34: 171.
    PubMedGoogle Scholar
  • 4 Eshiet I. T, Taylor D. A. H. 1966; Extractives from Fagara zanthoxyloides . Chemical Communications 14: 467.
    PubMedGoogle Scholar
  • 5 Essien E. M. 1974. Studies on the haemophilic diseases in Ibadan Nigeria, with a note on the prevalence of haemophilia in Ibarapa district. M.D. Thesis University of London;
    Google Scholar
  • 6 Gomori G. 1946; Buffers in the range pH 6.5 to 9.6. Proceedings of the Society for Experimental Biology, N. Y 62: 33.
    PubMedGoogle Scholar
  • 7 Hardisty R. M, Ingram G. I. C. 1965. Bleeding disorders, Investigation and Management. 274 Blackwell Scientific Publications; Oxford:
    Google Scholar
  • 8 Honig G. R, Farnsworth N. R, Ferenc C, Vida L. N. 1975; Evaluation of Fagara zanthoxyloides root extract in sickle cell anaemia blood in vitro. Lloydia 38: 387.
    PubMedGoogle Scholar
  • 9 Messmer M. W, Tin-wa M, Fong H. H. S, Farnsworth N. R, Abraham D. J, Trojanek J. 1972; Fagaronine, a new tumour inhibitor isolated from Fagara zanthoxyloides Lam (Rutaccear). Journal of Pharmaceutical Science 61: 1858.
    CrossrefPubMedGoogle Scholar
  • 10 Okogun J. L, Ekong D. E. U, Enyinihi V. U, Ayafor J. In preparation.
    PubMed
  • 11 Paris R, Moyse-Mignon Mme. 1947; Preliminary study of Fagara zanthoxyloides . Annals of Pharmacology 5: 410.
    PubMedGoogle Scholar
  • 12 Sofowora E. A, Isaacs W. A. 1971; Reversal of sickling and crenation in erythrocytes by the root extract of Fagara zanthoxyloides . Lloydia 34: 383.
    PubMedGoogle Scholar
  • 13 Sofowora E. A, Isaacs-Sodeye W. A, Ogunkoya L. O. 1975; Isolation and characterisation of an antisickling agent from Fagara zanthoxyloides root. Lloydia 38: 169.
    PubMedGoogle Scholar