Microvascular Haemostasis and the Effect of Local Stimulation and inhibition of Platelet Function. An Experimental Study in Rabbits

D Bergqvist; K.-E Arfors

doi:10.1055/s-0038-1648017

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1976; 36(01): 133-139
DOI: 10.1055/s-0038-1648017

Original Article

Schattauer GmbH

Microvascular Haemostasis and the Effect of Local Stimulation and inhibition of Platelet Function. An Experimental Study in Rabbits

D Bergqvist^*

¹Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden

,

K.-E Arfors

¹Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden

› Author Affiliations

Abstract

Summary

The local stimulation and inhibition of haemostatic plug formation was studied by local infusion and superfusion of different agents – ADP, thrombin, adenosine, heparin, prostaglandin E₁ (PGE₁) and laser injury. ADP and laser injury shortened venular haemostatic plug formation time whereas adenosine in the superfusate and PGE₁ prolonged it. Thrombin infusion had no effect but thrombin in the superfusate significantly stabilised the haemostatic plugs. It is suggested that ADP released from red cells is the most potent stimulator for haemostatic plug formation in the rabbit mesenteric microcirculation.

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References

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