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Thromb Haemost 1974; 32(02/03): 695-703
DOI: 10.1055/s-0038-1647739
Original Article
Schattauer GmbH

Measurement of the Platelet Response to Laserinduced Microvascular Injury

Ultrastructural Studies
T Hovig
1   Dept, of Pathology, Rikshospitalet, University of Oslo, Oslo, Norway, Dept, of Surgery, Univ. of Aberdeen, Aberdeen, Scotland and Dept, of Experimental Medicine, Pharmacia AB, Uppsala, Sweden
,
F. N McKenzie
1   Dept, of Pathology, Rikshospitalet, University of Oslo, Oslo, Norway, Dept, of Surgery, Univ. of Aberdeen, Aberdeen, Scotland and Dept, of Experimental Medicine, Pharmacia AB, Uppsala, Sweden
,
K.-E Arfors
1   Dept, of Pathology, Rikshospitalet, University of Oslo, Oslo, Norway, Dept, of Surgery, Univ. of Aberdeen, Aberdeen, Scotland and Dept, of Experimental Medicine, Pharmacia AB, Uppsala, Sweden
› Author Affiliations
Further Information

Publication History

Received 04 March 1974

Accepted 06 August 1974

Publication Date:
30 June 2018 (online)

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Summary

Microvascular injury was produced in rabbit mesentery and ear chamber preparations using a biolaser. Ultrastructural studies of the injury sites revealed damage to the endothelium which showed cytoplasmic swelling and flocculation. Complete destruction of the endothelium was not observed, indicating that sub endothelial structures were not exposed to blood flow. Microvascular thrombi which occurred at the sites of injury were composed of platelets which in general were loosely packed and showed minor alterations in shape and internal structure. Erythrocytes appeared to be heavily damaged by the laser injury. Fibrin was not observed. It is concluded that ADP may be released from red blood cells, and possibly from other sources, as a result of the laser injury, and that the platelet thrombus formation is induced by ADP.

 

  • References

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