Thromb Haemost 1974; 32(02/03): 665-669
DOI: 10.1055/s-0038-1647735
Original Article
Schattauer GmbH

Lysosomal Enzyme Activities in Platelets of Normal Individuals and of Patients with Gaucher’s Disease

S Yatziv
1   Department of Hematology and Pediatrics, Hebrew University Hadassah Medical School, Jerusalem
,
M White
1   Department of Hematology and Pediatrics, Hebrew University Hadassah Medical School, Jerusalem
,
A Eldor
1   Department of Hematology and Pediatrics, Hebrew University Hadassah Medical School, Jerusalem
› Author Affiliations
Further Information

Publication History

Received 11 June 1974

Accepted 10 August 1974

Publication Date:
30 June 2018 (online)

Summary

Five platelet lysosomal enzyme activities were estimated in 22 normal individuals and in 5 patients with Gaucher’s disease: ß-D-galactosidase, N-Acetyl-ß-D-glucosa-minidase, N-Acetyl-ß-D-galactosaminidase acid-phosphatase, and ß-D-glucuronidase.

In the 5 patients with Gaucher’s disease the specific activities for the first four of these enzymes were significantly higher than in normal individuals. The activity of acid-phosphatase, on the other hand, was lower in G. d. than in normals. The release of the 5 lysosomal enzymes from platelets upon incubation with thrombin was also examined in the same two groups. The only lysosomal enzyme that was not released from normal platelets was acid-phosphatase. In Gaucher’s patients, on the other hand, acid-phosphatase was invariably released from platelets when incubated with thrombin. The release of the other four enzymes from platelets of Gaucher patients was similar to that of normal controls.

 
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