The Resistance of Soluble Derivatives of Fibrinogen and the Sensitivity of Its Insoluble Forms to Fibrinolytic Degradation in Blood

Victor Gurewich; Andrzej Nowak; Izabella Lipinska; Boguslaw Lipinski

doi:10.1055/s-0038-1647727

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(02/03): 582-591
DOI: 10.1055/s-0038-1647727

Original Article

Schattauer GmbH

The Resistance of Soluble Derivatives of Fibrinogen and the Sensitivity of Its Insoluble Forms to Fibrinolytic Degradation in Blood

Victor Gurewich

¹Vascular Laboratory, Lemuel Shattuck Hospital, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02130

,

Andrzej Nowak

¹Vascular Laboratory, Lemuel Shattuck Hospital, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02130

,

Izabella Lipinska

¹Vascular Laboratory, Lemuel Shattuck Hospital, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02130

,

Boguslaw Lipinski

¹Vascular Laboratory, Lemuel Shattuck Hospital, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02130

› Author Affiliations

Abstract

Summary

The effect of naturally induced fibrinolytic activity on fibrinogen and certain soluble and insoluble derivatives was studied. Experiments were performed on blood removed after venous occlusion of the arm and immediately after death. A previously described electrophoretic method was used by which the heterogeneity of fibrinogen can be demonstrated directly in intact plasma. It was shown that fibrinogen, soluble fibrin monomer (FM) complexes and fibrin degradation products are resistant to degradation by naturally-induced fibrinolytic activity. By contrast, rapid lysis of fibrin, protamine sulfate (PS) precipitated fibrinogen, and PS and ethanol induced gels of FM occurred. The observations are believed relevant to our understanding of the pathway of fibrinogen and FM catabolism and the interpretation of the origin of serum FDP.

Full Text

References

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