Severe Factor V Deficiency with Prolonged Bleeding Time

Kees Bkeederveld; Eric A. van Royen; Jan W. ten Cate

doi:10.1055/s-0038-1647722

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(02/03): 538-548
DOI: 10.1055/s-0038-1647722

Original Article

Schattauer GmbH

Severe Factor V Deficiency with Prolonged Bleeding Time

Kees Bkeederveld

¹Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands

,

Eric A. van Royen

¹Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands

,

Jan W. ten Cate

¹Coagulation Laboratory, Department of Haematology, University Hospital “ Wilhelmina Gasthuis”, Amsterdam, The Netherlands

› Author Affiliations

Abstract

Summary

A patient with two congenital defects, i.e. a severe factor V deficiency and an aortic coarctation is described. Arguments for a dominant mode of inheritance of the factor V deficiency are presented. A coinciding haemostatic defect consisting of a prolonged bleeding time, which could be corrected by fresh plasma and cryoprecipitate, and a decreased platelet retention in the glass bead test disappeared after surgical correction of the coarctation.

Extensive platelet studies failed to show any further defect.

Full Text

References

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