Action of Trypsin on Amidinated Fibrinogen

H. M Phillips; J Lyndal York

doi:10.1055/s-0038-1647714

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(02/03): 465-467
DOI: 10.1055/s-0038-1647714

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Action of Trypsin on Amidinated Fibrinogen

H. M Phillips

¹Department of Biochemistry, University of Arkansas Medical Center, Little Rock, Arkansas 72201

,

J Lyndal York

¹Department of Biochemistry, University of Arkansas Medical Center, Little Rock, Arkansas 72201

› Author Affiliations

Abstract

Summary

A study of the action of trypsin on fibrinogen with lysine side chains chemically blocked by amidination was undertaken to determine whether trypsin attacks arginine or lysine linkages in fibrinogen in order to render it nonclottable. The data suggests that trypsin attacks arginine site(s).

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References

References
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