Erythrocytes and Blood Coagulation

Summary

The action of intact and hemolyzed red cells in in vitro clotting systems is analyzed against the background of the clinical manifestations of red cell procoagulants in incompatible transfusions and hemolytic anemias in man and in experimental animals. It is suggested that the nature of the lesion in the stroma may be of importance in determining the biological effects.

• References

• 1 Ambrus J. L, Ambeus C. M, Munson A. 1969. Model systems for the study of thrombosis. In: Johnson S. A, Guest M. M. (eds.), Dynamics of Thrombus Formation and Dissolution. Lippincott Philadelphia: Pennsylvania; 182.
• 2 Ashkinazi IYa. 1969; Effect of adrenalin on ability of intact erythrocytes to increase plasma thromboplastin activity. Bulletin of Experimental Biology and Medicine (U.S.S.R.) 67: 1.
• 3 Astrowe P. S. 1922; Hemolysis following transfusion. Journal of the American Medical Association 79: 1511.
• 4 Barratt J. O.W. 1913; On fibrinaemia. Journal of Pathology and Bacteriology 17: 303.
• 5 Barratt J. O.W, Yorke W. 1914; The production of general symptoms in haemoglobenaemia. British Medical Journal 06: 235.
• 6 Bentley Jr. H. P, Krivit W. 1960; An assay of antihemophilic globulin activity in the carrier female. Journal of Laboratory and Clinical Medicine 56: 613.
• 7 Biggs R, Douglas A. S, MacFarlane R. G. 1953; The formation of thromboplastin in human blood. Journal of Physiology 119: 89.
• 8 Biggs R, Denson K. W.E, Riesenberg D, McIntyre C. 1968; The coagulant activity of platelets. British Journal of Haematology 15: 283.
• 9 Birndorf N. I, Lopas H. 1970; Intravascular coagulation in cynomologus monkeys produced by red blood cell stroma. Clinical Research 18: 398.
• 10 Bradlow E. A. 1961; Liberation of material with platelet-like coagulant properties from intact red cells and particularly from reticulocytes. British Journal of Haematology 07: 476.
• 11 Brown D. L. 1970; Acute complement-mediated haemolysis in the rabbit. British Journal of Haematology 19: 499.
• 12 Cochin A, Dewoskin R, Moss G. S. 1972. Stroma free solution Correction of anticoagulant properties. Proceedings of the Third Congress of the International Society of Thrombosis and Haemostasis. Washington, D.C: (Abstract).
• 13 Crosby W. H, Stefanini M. 1952; Pathogenesis of the plasma transfusion reaction with especial reference to the blood coagulation system. Journal of Laboratory and Clinical Medicine 40: 374.
• 14 Dodge J. T, Mitchell C, Hanahan D. J. 1963; The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Archives of Biochemistry and Biophysics 100: 119.
• 15 Evensen S. A, Jeremic M. 1970; Platelets and the triggering mechanism of intra-vascular coagulation. British Journal of Haematology 19: 33.
• 16 Garatun-Tjeldsto E, Krüger K. S. 1971; Age dependent variation in coagulation properties and heparin response of human blood hemolysate and plasma. Experimental Gerontology 06: 125.
• 17 Gavras H. et al. 1971; Microangiopathic hemolytic anemia and the development of the malignant phase of hypertension. Circulation Research, Suppl. II, 28 29: 127.
• 18 Georgatsos J. C, Hussey C. V, Quick A. J. 1955; Nature and action of a new clotting factor obtained from erythrocytes. American Journal of Physiology 181: 30.
• 19 Hamilton P. B, Farr L. E, Hiller A, Van Slyke D. D. 1947; Preparation of hemoglobin solutions for intra-venous infusion. Journal of Experimental Medicine 84: 455.
• 20 Hoffman J. G. 1958; Physiological characteristics of human red blood cell ghosts. Journal of General Physiology 42: 9.
• 21 Hussey C. V, Kaser M. M. 1956; Erythrocytin, a clotting factor from erythrocytes: Its action and purification. Federation Proceedings 15: 279.
• 22 Jansarik H, Koppler E, Lasch M. G. 1972; Experimentelle Immunhämolyse und Blutgerinnung. Thrombosis et Diathesis Haemorrhagica 26: 22.
• 23 Krasik Y. D, Abdulkadyrov K. M. 1971; Blood coagulation and the role of erythrocytes in the process of haemostasis in hypoplastic anemia. Gemat. Pereli. Krovi 16: 35.
• 24 Krevans J. R, Jackson D. P, Conley C. L, Hartman B. C. 1957; The nature of the hemorrhagic disorder accompanying hemolytic transfusion reactions in man. Blood 12: 834.
• 25 Lasch H. G, Heene D. L. 1967; Diagnosis of intravascular coagulation and fibrinolysis. Thrombosis et Diathesis Haemorrhagica, Suppl 26: 351.
• 26 Levine E. C, Segall H. N. 1922; Post transfusion reactions. Surgical Gynecology and Obstetrics 35: 313.
• 27 Lopas H, Birndorf N. I. 1972; Hemolysis and intravascular coagulation due to incompatible red cell transfusion in isoimmunized monkeys. British Journal of Haematology 21: 399.
• 28 Lopas H, Birndorf N. I, Robboy S. J. 1971; Experimental transfusion reactions and disseminated intravascular coagulation produced by incompatible plasma in monkeys. Transfusion 11: 196.
• 29 Lopas H, Birndorf N. I, Bell Jr. C. E, Robboy S. J, Fortwengler H. P, Biddison N. E. 1972; Haemolysis and intravascular coagulation due to incompatible red cells in isoimmunized monkeys. British Journal of Haematology 23: 765.
• 30 Lorie Y. I, Orlova L. D. 1964; Changes in clotting system in blood in Marchiafava-Micheli disease. Federation Proceeding Transactions, Suppl 23: 1226.
• 31 Marcus A. J. 1966; The role of lipids in blood coagulation. Advances in Lipid Research 04: 1.
• 32 McKay D. G, Hardaway R. M, Wahle G. H, Edelstein R, Tartock D. E. 1955; Alterations in blood coagulation mechanism after incompatible blood transfusion. American Journal of Surgery 89: 583.
• 33 McKellar M, Dacie J. V. 1958; Thromboplastic activity of the plasma in paroxysmal nocturnal haemoglobinuria. British Journal of Haematology 04: 404.
• 34 de Matteis F, Vulpis N. 1960; The influence of blood corpuscles on clot firmness: Thromboelastographic observations. Thrombosis et Diathesis Haemorrhagica 04: 71.
• 35 Mey U, Hesse P. 1966; Über den Einfluß des erythrozytins auf die Blutgerinnung. Blut 13: 30.
• 36 O’Brien J. R. 1959; Some effects on blood coagulation of erythrocytes and other cells. Journal of Clinical Pathology 12: 45.
• 37 O’Brien J. R. 1961. In: Johnson S. A, Monto R. W, Rebuck J. W, Horn Jr. R. C. (eds.) Bloods Platelets. Little Brown; Boston, Massachusetts: 323.
• 38 Quick A. J. 1957 Hemorrhagic Diseases Lea and Febiger Philadelphia Pennsylvania.
• 39 Quick A. J, Hussey C. V. 1955; Erythrocytin, a new clotting factor from erythrocytes : Its value in the study of hemophilia. Journal of Laboratory and Clinical Medicine 46: 940.
• 40 Quick A. J, Georgatsos J. G, Hussey C. V. 1954; The clotting activity of human erythrocytes: Theoretical and clinical implications. American Journal of Medical Sciences 228: 207.
• 41 Quick A. J, Hickey M. E. 1960; Influence of erythrocytes on the coagulation of blood. American Journal of Medical Sciences 239: 51.
• 42 Quick A. J, Hickey M. E. 1961; Hemolysate prothrombin consumption time: A new test for thromboplastinogenic coagulation defects. Journal of Laboratory and Clinical Medicine 57: 290.
• 43 Quick A. J. 1966. Hemorrhagic Diseases and Thrombosis. Second edition,. Lea and Febiger, Philadelphia: Pennsylvania.;
• 44 Quick A. J, Hussey C. V. 1956; Hemophilia: Quantitative studies of the coagulation defect. Archives of Internal Medicine 97: 524.
• 45 Rabiner S. F, Friedman L. H. 1968; The role of intravascular hemolysis and the reticuloendothelial system in the production of a hypercoagulable state. British Journal Haematology 14: 105.
• 46 Rabiner S. F, Helbert J. R, Lopas H, Friedman L. H. 1967; Evaluation of a stroma-free hemoglobin solution for use as a plasma expander. Journal of Experimental Medicine 126: 1127.
• 47 Redman C. M. 1971; Phospholipid metabolism in intact and modified erythrocyte membranes. Journal of Cell Biology 49: 35.
• 48 Redman C. M. 1972; Proteolipid involvement in human erythrocyte membrane function. Biochemica et Biophysica Acta 282: 123.
• 49 Rock R. C, Bove J. R, Nemerson Y. 1969; Heparin treatment of intravascular coagulation accompanying hemolytic transfusion reactions. Transfusion 09: 57.
• 50 Sachs J. R, Knauf P. A, Dunham P. B. 1974. Transport through red cell membranes. In: Surgenor DMacN. (ed.) The Bed Blood Cell. second edition,. Academic Press; New York.:
• 51 Schmidt P. J, Holland P. V. 1967; Pathogenesis of the acute renal failure associated with incompatible transfusion. The Lancet 02: 1169.
• 52 Scott R. B, Robb-Smith A. H.T, Scowen E. F. 1938; The Marchiaf-Micheli syndrome of nocturnal haemoglobinuria with haemolytic anemia. Quarterly Journal of Medicine 07: 95.
• 53 Seldon T. H. 1949; Transfusion reactions among patients under general anesthesia. Mississippi Valley Medical Journal 71: 124.
• 54 Semar M, Skoza L, Johnson A. J. 1969; Partial purification and properties of a plasminogen activator from human erythrocytes. Journal of Clinical Investigation 48: 1777.
• 55 Shinowara G. 1951; Enzyme studies on human blood. Journal of Laboratory and Clinical Medicine 38: 11.
• 56 Shulman N. R, Weinrach R. S, Libre E. P, Andrews H. L. 1965; The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura. Transaction of the Association of American Physicians 78: 374.
• 57 Teorell T. 1952; Permeability properties of erythrocyte ghosts. Journal of General Physiology 35: 669.
• 58 Triantaphyllopoulos E. 1971; Hemoglobin, inhibitor of contact phase of blood coagulation. Life Sciences 10: 813.
• 59 Triantaphyllopoulos E. 1972. Inhibition of plasminogen activation by hemoglobin. Proceedings of the Illrd Congress of the International Society of Thrombosis and Haemostasis. Washington D.C: August, 1972. 308 (abstract).
• 60 Triantaphyllopoulos E. 1973; Effect of erythrocytes on coagulation and fibrinolysis: Pathogenesis of intravascular coagulation following intravascular hemolysis. Thrombosis et Diathesis Haemorrhagica, Suppl 53: 243.
• 61 Troup S. B, Reed C. F, Marinetti G. Y, Swisher S. N. 1960; Thromboplastic factors in the platelets and red blood cells : Observations on their chemical nature and function in vitro coagulation. Journal of Clinical Investigation 39: 342.
• 62 Troup S. B, Reed C. F, Marinetti G. V, Swisher S. N. 1961. In: Johnson S. A, Monto R. W, Rebuck J. W, Horn Jr. R. C. (eds.), Blood ‘platelets. 289 Little Brown; Boston, Massachusetts.:
• 63 Walther B. 1956; Über die Gerinnungsaktivität hämolysierter menschlicher Erythrozyten. Blut 02: 211.
• 64 Weber U, Schenck W, Kunzer W. 1971; Über den Einfluß intakter Erythrozyten auf verschiedene Gerinnungskriterien. Med. Welt 22: 1662.
• 65 Weed R. I, Reed C. F, Berg G. 1963; Is Hemoglobin an Essential Structural Component of Human Erythrocyte Membranes. Journal of Clinical Investigations 42: 581.
• 66 Wooldridge L. (1886a): Note on the Relation of the Red Blood Corpuscles to Coagulation. Practitioner 38: 187.
• 67 Wooldridge L. (1886b): Über Intravasculäre Gerinnungen. Archiv für Physiologie (Leipzig) 397.