Effects of Alpha and Beta Receptor Stimulating and Blocking Agents on Experimental Disseminated Intravascular Coagulation

M Moriau; H Noel; R Masure

doi:10.1055/s-0038-1647682

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1974; 32(01): 157-170
DOI: 10.1055/s-0038-1647682

Original Article

Schattauer GmbH

Effects of Alpha and Beta Receptor Stimulating and Blocking Agents on Experimental Disseminated Intravascular Coagulation

M Moriau

¹Laboratory for Haemostasis and Thrombosis Research, University of Louvain, Louvain, Belgium

,

H Noel^*

¹Laboratory for Haemostasis and Thrombosis Research, University of Louvain, Louvain, Belgium

,

R Masure

¹Laboratory for Haemostasis and Thrombosis Research, University of Louvain, Louvain, Belgium

› Author Affiliations

Abstract

Summary

In this experimental study on rabbits, we compare the haemostatic and histological changes observed in animals with disseminated intravascular coagulation (DIC) induced by thrombin perfusion (100 u/kg/hr during 3 hours) with or without preventive administration of alpha and beta receptor stimulating or blocking agents.

Both alpha and beta receptor stimulating agents enhance the disorders induced by thrombin alone, while alpha or beta blocking agents reduce them.

This favourable action is still more pronounced with the combination of these two last types of drugs.

The modifications observed appear to be related to changes in platelet function.

Full Text

References

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