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Thromb Haemost 1974; 32(01): 149-156
DOI: 10.1055/s-0038-1647681
Original Article
Schattauer GmbH

The Hemostatic Effect of Bovine Peptide-B from Fibrinogen

A. J OSBAHR
1   National Institute of Arthritis, Metabolism and Digestive Diseases National Institutes of Health, Public Health Service U. S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
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Publication History

Received for publication 01 March 1974

Accepted for publication 09 May 1974

Publication Date:
30 June 2018 (online)

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Summary

Bovine peptide-B from fibrinogen was active in the hemostasis of rat tail arterioles. The time of bleeding exhibits an inverse log proportionality to the concentration of bovine peptide-B. The peptide produced a 10-fold decrease in the time of bleeding at the highest concentration tested. Prolonged incubation of the peptide with the system was unnecessary and it appeared to participate immediately as a hemostatic agent.

These findings suggest that hemostasis was due to vasoconstriction since coagulation time remained constant as the bleeding time decreased with increasing concentration of peptide-B. Bovine peptide-B is interpreted as a physiological substance which probably acts on some smooth muscle receptor.

 

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