22. Role of Intravenous Magnesium sulphate in spinal surgery for hypotensive anesthesia

Background: This randomized, double-blind placebo controlled study was undertaken to evaluate effect of intravenous magnesium sulphate for hypotensive anesthesia in patient for spinal surgery. Materials and Methods: Sixty patients undergoing spinal surgery were included in two parallel groups. The magnesium group (M) received magnesium sulphate 40 mg/kg as a bolus before induction of anesthesia and 10 mg/kg/hr by continuous infusion during operation through out surgery. The control group (C) as above received isotonic saline solution both as bolus and infusion at the same rate. Result: The surgical time was reduced in magnesium group [170 (40) minutes] vs. [180 (45) minutes] in control group. The anesthetic requirements (fentanyl, vecuronium, isoflurane), mean arterial pressure (P < 0.005) and heart rate (P < 0.005) were also significantly reduced. However, the anesthetic time was longer as observed thus a prolongation in emergence from anaesthesia. Conclusion: Intravenous magnesium sulphate led to a significant decrease in mean arterial pressure, heart rate, and duration of surgery. It also alters anesthetic dose requirements.

No conflict of interest has been declared by the author(s).