Isolated Metastatic Carcinoma to the Hamate Bone: The First Manifestation of an Occult Malignancy

Abstract

A 60-year-old man presented with swelling, pain, and tenderness at the ulnar side of his left wrist. Imaging studies demonstrated an osseous lesion in the left hamate bone. Histopathology study of the lesion revealed that the lesion was an isolated osseous metastatic carcinoma. The metastasis was the first presentation of this occult malignancy. The patient was treated with radiotherapy and chemotherapy; however, he expired 20 months after the diagnosis. This is a level IV study.

Keywords - acrometastasis - carpal metastasis - hamate - hand metastasis - wrist metastasis

• References

• 1 Amadio PC, Lombardi RM. Metastatic tumors of the hand. J Hand Surg Am 1987; 12 (02) 311-316
• 2 Kerin R. The hand in metastatic disease. J Hand Surg Am 1987; 12 (01) 77-83
• 3 Afshar A, Farhadnia P, Khalkhali H. Metastases to the hand and wrist: an analysis of 221 cases. J Hand Surg Am 2014; 39 (05) 923-932
• 4 Hayden RJ, Sullivan LG, Jebson PJ. The hand in metastatic disease and acral manifestations of paraneoplastic syndromes. Hand Clin 2004; 20 (03) 335-343
• 5 Abrahams TG. Occult malignancy presenting as metastatic disease to the hand and wrist. Skeletal Radiol 1995; 24 (02) 135-137
• 6 Ahlmann ER, Greene NW, Menendez LR, Stevanovic MV. Unusual locations for metastatic malignancy of the hand: a report of three cases. J Surg Orthop Adv 2008; 17 (04) 267-270
• 7 Borgohain B, Borgohain N, Khonglah T, Bareh J. Occult renal cell carcinoma with acrometastasis and ipsilateral juxta-articular knee lesions mimicking acute inflammation. Adv Biomed Res 2012; 1: 48
• 8 Buckley N, Peebles BrownDA. Metastatic tumors in the hand from adenocarcinoma of the colon. Dis Colon Rectum 1987; 30 (02) 141-143
• 9 Caglar M, Ceylan E. Isolated carpal bone metastases from bronchogenic cancer evident on bone scintigraphy. Clin Nucl Med 2001; 26 (04) 352-353
• 10 Craigen MA, Chesney RB. Metastatic adenocarcinoma of the carpus: a case report. J Hand Surg [Br] 1988; 13 (03) 306-307
• 11 Esther RJ, Bos GD. Management of metastatic disease of other bones. Orthop Clin North Am 2000; 31 (04) 647-659
• 12 Gaston RG, Lourie GM, Scott CC. Isolated metastatic lesion of the trapezium. Am J Orthop 2008; 37 (08) E144-E145
• 13 Keramidas E, Brotherston M. Extensive metastasis to the hand from undiagnosed adenocarcinoma of the lung. Scand J Plast Reconstr Surg Hand Surg 2005; 39 (02) 113-115
• 14 Park KH, Rho YH, Choi SJ. et al. Acute arthritis of carpal bones secondary to metastatic gastric cancer. Clin Rheumatol 2006; 25 (02) 258-261
• 15 Reichert B, Hoch J, Plötz W, Mailänder P, Moubayed P. Metastatic clear-cell sarcoma of the capitate. A case report. J Bone Joint Surg Am 2001; 83-A (11) 1713-1717
• 16 Rinonapoli G, Caraffa A, Antenucci R. Lung cancer presenting as a metastasis to the carpal bones: a case report. J Med Case Reports 2012; 6 (01) 384
• 17 Roushdi I, Jeswani T, Clark D. Lymphoma presenting as a metastasis to the hand. J Hand Surg Eur Vol 2012; 37 (03) 286-287
• 18 Song Y, Yao J. Trapezial metastasis as the first indication of primary non-small cell carcinoma of the lung. J Hand Surg Am 2012; 37 (06) 1242-1244
• 19 Stahl S, Santos StahlA, Lotter O, Pfau M, Perner S, Schaller HE. Palliative surgery for skeletal metastases from melanoma in the scaphoid—a critical case report appraisal. J Plast Reconstr Aesthet Surg 2012; 65 (08) 1111-1115
• 20 Stanković M, Lalić I, Djuričin A, Gvozdenović N. Isolated metastasis of lung cancer to carpal bones. Vojnosanit Pregl 2017; 74 (11) 1078-1083
• 21 Strooker JA, Maas M, Bulkmans N, Kreulen M. Painful metastasis in the lunate bone as the first symptom of a Pancoast tumor; a case report and review of the literature. J Hand Microsurg 2015; 7 (02) 343-345
• 22 Tolo ET, Cooney WP, Wenger DE. Renal cell carcinoma with metastases to the triquetrum: case report. J Hand Surg Am 2002; 27 (05) 876-881
• 23 Tomas X, Conill C, Combalia A, Pomes J, Castel T, Nicolau C. Malignant melanoma with metastasis into the capitate. Eur J Radiol 2005; 56 (03) 362-364
• 24 Wurapa RK, Bickel BA, Mayerson J, Mowbray JG. Metastatic esophageal adenocarcinoma of the carpus. Am J Orthop 2010; 39 (06) 283-285
• 25 Piccioli A, Maccauro G, Spinelli MS, Biagini R, Rossi B. Bone metastases of unknown origin: epidemiology and principles of management. J Orthop Traumatol 2015; 16 (02) 81-86
• 26 Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004; 350 (16) 1655-1664
• 27 Judit M, Zoltan S, Rita P. et al. Bone metastasis with histology different from the primary lung cancer and the skin metastasis. Transl Biomed 2015; 6 (02) 1-3