CC BY-NC-ND 4.0 · Laryngorhinootologie 2018; 97(S 02): S116-S117
DOI: 10.1055/s-0038-1640115
Poster
Onkologie: Oncology

Epidemiological characteristics and survival rates in laryngeal cancer patients in Western Greece

T Papadas
1   HNO-Uni-Klinik Patras, Patras, Greece
,
C Avdulla
2   Abteilung für Hygiene, Medizinische Fakultät, Universität Patras, Rio Patras, Griechenland
,
E Jelastopulu
2   Abteilung für Hygiene, Medizinische Fakultät, Universität Patras, Rio Patras, Griechenland
,
V Danielides
3   HNO-Uni-Klinik Patras, Rio Patras, Griechenland
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    Introduction:

    The purpose of this study was to investigate overall survival (OS) and prognostic factors for OS among all-stage laryngeal cancer patients after total laryngectomy over 12 years' follow-up at a single center in Greece.

    Methods:

    A retrospective cohort study was performed, including 115 patients with primary laryngeal carcinoma diagnosed and treated in the ENT Clinic of a University Hospital during 2005 – 2016. The prognostic impact of age, occupation, smoking/alcohol, subsite, tumor, node and metastasis staging, were evaluated using Kaplan-Meier analyses.

    Results:

    During the last 12 years high percentage of malignant tumors of the larynx was seen in men (96.5%) compared to women (3.5%), the mean age was 62 years. Almost all were smokers (mean 136 pack years) and 51 (44.3%) heavy alcohol users. Postoperative staging indicated 34.8% stage III and 60.9% stage IV. Tumor grading showed 18 (15.7%), 74 (64.3%) and 20 (17.4%) tumors classified as G3, G2, and G1, respectively. The most common location was glottis (51.3%), followed by supraglottis (45.2%). More than half of the patients were farmers (24.3%), builders (19.1%), and self-employed (15.7%). During the follow-up (mean 42 months), a total of 65 (56.5%) patients died, and 45.3% from causes related to their disease. Five-year OS was 48%, 45% and 51% for the entire cohort and for glottic and supraglottic cancer, respectively. Moreover, OS was associated with tumor, node and metastasis staging, smoking/alcohol and post-surgical modality of treatment.

    Conclusion:

    In conclusion, our study revealed lower survival rates as known from the literature. Various prognostic factors play an important role in the progression and overall survival in patients with malignant laryngeal tumors after total laryngectomy.


    #

    No conflict of interest has been declared by the author(s).

    Professor Theodoros Papadas
    HNO-Uni-Klinik Patras,
    Universitätsklinikum, 26500,
    Rio Patras,
    Greece   

    Publication History

    Publication Date:
    18 April 2018 (online)

    © 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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