Comparison of Risk Factors for Hypertrophic Osteodystrophy, Craniomandibular Osteopathy and Canine Distemper Virus Infection

T. A. Munjar; Connie C. Austin; G. J. Breur

doi:10.1055/s-0038-1632606

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 1998; 11(01): 37-43
DOI: 10.1055/s-0038-1632606

Original Research

Schattauer GmbH

Comparison of Risk Factors for Hypertrophic Osteodystrophy, Craniomandibular Osteopathy and Canine Distemper Virus Infection

Authors

T. A. Munjar

¹From the Departments of Veterinary Clinical Sciences, West Lafayette, Indiana, USA
Connie C. Austin

²Veterinary Pathobiology, Purdue University, School of Veterinary Medicine, West Lafayette, Indiana, USA
G. J. Breur

¹From the Departments of Veterinary Clinical Sciences, West Lafayette, Indiana, USA

Abstract

Summary

An analysis of hypertrophic osteodystrophy (HOD), craniomandibular osteopathy (CMO) and canine distemper virus (CDV) infection was undertaken. Risk factors (age, breed, sex, neuter status, weight, geographical and seasonal distribution) of the three diseases were determined and compared. Patient records were searched using the Veterinary Medical Database (VMDB) during the period of 1980 through 1989. This search identified 131 cases of HOD, 68 cases of CMO and 1,757 of CDV infection. Dogs less than six months of age were identified to be at greatest risk for HOD, CMO and CDV. The Great Dane, Cairn Terrier and the Greyhound were identified to be at highest risk for HOD, CMO and CDV infection, respectively. Males puppies were twice as likely to develop HOD. We concluded, from the risk factors analyzed, that risk factors for HOD, CMO or CDV infection were not similar.

Patient information was obtained from clinical cases of 16 veterinary teaching hospitals to examine a possible relationship between Hypertrophic Osteodystrophy (HOD), Craniomandibular Osteopathy (CMO), and Canine Distemper Virus (CDV) infections. Risk factors for each disease were determined. Subjective comparison of risk factors for HOD and CMO did not support the notion of a relationship between HOD and CMO. In addition, no evidence for a possible relationship between CDV and HOD or CMO was found.

Keywords

Hypertrophic osteodystrophy - craniomandibular osteopathy - canine distemper virus

Full Text

References

REFERENCES
1 Lenehan TM, Fetter AW.. Hypertrophic Osteodystrophy. In Textbook of Small Animal Orthopedics.. Newton CD, Nunamaker DM. (ed). Philadelphia, PA: JB Lippincott; 1985: 597-601.
2 Littlewort MCG. Letters to the Editor, Tumour-like Exostosis on the Bones of the Head in Puppies. Vet Rec 1958; 70: 977-8.
3 Holmes JR. Suspected Skeletal Scurvy in the Dog. Vet Rec 1962; 74: 801-12.
4 Väänänen M, Wikman L. Scurvy as a cause of osteodystrophy. J Small Anim Pract 1979; 20: 491-500.
5 Riser W. Radiographic Differential Diagnosis of Skeletal Diseases of Young Dogs. J Am Vet Radiol Soc 1964; 5: 15-27.
6 Rendano VT, Dueland R, Sifferman RL. Letter to the editor, Metaphyseal Osteopathy: (Hypertrophic Osteodystrophy). J Small Anim Pract 1977; 18: 679-83.
7 Woodard JC. Canine Hypertrophic Osteodystrophy, A Study of the Spontaneous Disease in Littermates. Vet Pathol 1982; 19: 337-54.
8 Watson ADJ, Blair RC, Farrow BRH. et al Hypertrophic Osteodystrophy in the Dog. Aust Vet J 1973; 49: 433-40.
9 Alexander JW. Hypertrophic Osteodystrophy. Canine Pract 1978; 5: 48-52.
10 Watson ADJ, Adams WM, Thomas CB. Craniomandibular Osteopathy in Dogs. Comp Cont Ed 1995; 17: 911-22.
11 Padgett GA, Mostosky UV. Animal Model: The mode of Inheritance of Craniomandibular Osteopathy in West Highland White Terrier Dogs. Am J Med Genet 1986; 25: 9-13.
12 Riser WH, Parkes LJ, Shirer JF. Canine Craniomandibular Osteopathy. J Am Vet Radiol Soc 1967; 8: 23-30.
13 Grøndalen J. Metaphyseal osteopathy (hypertrophic osteodystrophy) in growing dogs. A clinical study. J Small Anim Pract 1976; 17: 721-35.
14 Meier H, Clark ST, Schnelle GB, Will DH. Hypertrophic Osteodystrophy Associated with Disturbance of Vitamin C Synthesis in Dogs. J Am Vet Med Assoc 1957; 130: 483-91.
15 Watson ADJ. Hypertrophic osteodystrophy: Vitamin C deficiency, overnutrition or infection?. Aust Vet Pract 1978; 8: 107-8.
16 Hedhammer A, Wu F, Krook L. et al Overnutrition and Skeletal Disease: An Experimental Study in Growing Great Dane Dogs. Cornell Vet 1974; 64 (Suppl. 05) (suppl) 9-160.
17 Teare JA, Krook L, Kallfelz FA, Hintz HF. Ascorbic Acid Deficiency and Hypertrophic Osteodystrophy in the Dog: A Rebuttal. Cornell Vet 1979; 69: 384-401.
18 Bennett D. Nutrition and bone disease in the dog and cat. Vet Rec 1976; 98: 313-20.
19 Bellah JR. Hypertrophic Osteodystrophy. In Disease Mechanisms in Small Animal Surgery.. Bojrab MJ. (ed). Philadelphia, PA: Lea and Febiger; 1993: 858-64.
20 deVries HW, VanDeWatering CC. Predisone in the treatment of canine craniomandibular osteopathy. Neth J Vet Sci 1973; 5: 123-31.
21 Watson ADJ, Huxtable CRR, Farrow BRH. Craniomandibular osteopathy in Doberman Pinschers. J Small Anim Pract 1975; 16: 11-9.
22 Schulz S. A case of craniomandibular osteopathy in a Boxer. J Small Anim Pract 1978; 19: 749-57.
23 Pool RR, Leighton RL. Craniomandibular Osteopathy in a Dog. J Am Vet Med Assoc 1969; 154: 657-60.
24 Riser WH, Newton CD. Craniomandibular osteopathy. In Textbook of Small Animal Orthopedics.. Newton CD, Nunamaker DM. (ed). Philadelphia, PA: JB Lippincott; 1985: 621-6.
25 Battershell D. What is your diagnosis?. J Am Vet Med Assoc 1969; 155 1735;
26 Carithers RW, Mitten RW, Taylor J. What is your diagnosis?. J Am Vet Med Assoc 1977; 171: 369.
27 Taylor SM, Remedios A, Myers S. Craniomandibular osteopathy in a Shetland sheepdog. Can Vet J 1995; 36: 437-9.
28 Hathcock JT. Craniomandibular osteopathy in an English Bulldog. J Am Vet Med Assoc 1982; 181: 389.
29 Burk RL. Craniomandibular Osteopathy in a Great Dane. J Am Vet Med Assoc 1976; 169: 635-6.
30 Watkings JD, Bradley R. Craniomandibular Osteopathy in a Labrador Puppy. Vet Rec 1966; 79: 262-4.
31 Riser WH. What is your diagnosis?. J Am Vet Med Assoc 1966; 148: 1543-4.
32 Schulz KS, Payne JT, Aronson E. Escherichia coli bacteremia associated with hypertrophic osteodystrophy in a dog. J Am Vet Med Assoc 1991; 199: 1170-3.
33 Gordon MT, Anderson DC, Sharpe PT. Canine Distemper Virus Localized in Bone Cells of Patients with Paget’s Disease. Bone 1991; 12: 195-201.
34 Mee AP, Gordon MT, May C. et al Canine Distemper Virus Transcripts Detected in the Bone Cells of Dogs with Metaphyseal Osteopathy. Bone 1993; 14: 59-67.
35 Merino N, Rodriguez ME, Torres O. et al Osteodistrofia hipertrófica en cachorros de las razas pastor alemán y Doberman. Rvta Cub Cienc Vet 1988; 4: 305-7.
36 Haaland M. Hypertrofisk Osteodystrofi hos noen briard valper. Norsk Veterinaertidsskrift 1987; 99 (02) 142-4.
37 Šehiŧ VM, Modriŧ Z, Butkoviŧ V.. Die hypertrophische Osteodystrophie beim Hund: Zwei Fälle bei jungen Deutschen Schäferhunden. Kleintierpraxis 1987; 32: 13-4.
38 Alexander JW. Selected Skeletal Dyplasias: Craniomandibular Osteopathy, Multiple Cartilaginous Exostoses, and Hypertrophic Osteodystrophy. Vet Clin North Am 1983; 13: 55-70.
39 Priester WA, McKay FW. The occurrence of tumors in domestic animals. Monogr Natl Cancer Inst 1980; 54: 1-10.
40 Priester WA. (ed). Standard nomenclature of veterinary diseases and operations. 2nd ed. DHEW Publ No. (NIH). 76-1028. Washington, DC: US Government Printing Office; 1976
41 Glickman LT, Glickman NW, Pérez CM. et al Analysis of risk factors for gastric dilatation and dilatation-volvulus in dogs. J Am Vet Med Assoc 1994; 204: 1465-71.
42 Johnson JA, Austin C, Breur GJ. Incidence of Canine Appendicular Musculoskeletal Disorders in 16 Veterinary Teaching Hospitals from 1980 through 1989. Vet Comp Orthop Traumatol 1994; 7: 56-69.
43 SAS Institute Inc. SAS/STAT User’s Guide, Version 6. 4th ed. SAS Institute Inc.; Cary, NC: 1989. b 2 846.
44 Dean AG, Dean JA, Burton AH, Dicker RC.. Epi Info Version 5. A word processing, database, and statistics program for epidemiology on microcomputers.. Stone Mountain, GA: USD, Inc; 1990: 384.
45 Hosmer DW, Lemeshow S.. Applied Logistics Regression. New York, NY: John Wiley & Sons; 1980: 301.
46 Hansson K, Trowald-Wigh G, Ekman S. Osteopathies Associated with Leucocyte Adhesion Protein Deficiency (LAD) in Irish Setters. Abstract. Vet Radiol 1994; 35: 238.
47 Patterson DF, Aguirre GA, Fyfe JC, Giger U, Green PL, Haskins ME, Jezyk PF, Meyers-Wallen VN. Is this a genetic disease?. JSAP 1989; 30: 127-39.