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Nuklearmedizin 1992; 31(04): 142-144
DOI: 10.1055/s-0038-1629615
Kasuistik
Schattauer GmbH

Kortikale Dysplasie als epileptogener Fokus: Verminderte Bindung von I-Iomazenil bei unauffälliger 99mTc-HMPAO SPECT

Cortical Dysplasia as an Epileptogenic Focus: Reduced Binding of 123I-Iomazenil with Normal Uptake in 99mTc-HMPAO SPECT
P. Bartenstein
1   Aus der Klinik und Poliklinik für Nuklcarmcdizin (Dir.: Prof. Dr. Dr. O. Schober), Westfälischen Wilhelms-Universität Münster, FRG
,
C. Lehmenkühler
2   der Klinik und Poliklinik für Neurologie (Dir.: Prof. Dr. G. G. Brune), Westfälischen Wilhelms-Universität Münster, FRG
,
J. Sciuk
1   Aus der Klinik und Poliklinik für Nuklcarmcdizin (Dir.: Prof. Dr. Dr. O. Schober), Westfälischen Wilhelms-Universität Münster, FRG
,
G. Schuierer
3   dem Institut für Klinische Radiologie (Dir.: Prof. Dr. P. E. Peters) der Westfälischen Wilhelms-Universität Münster, FRG
› Author Affiliations
Further Information

Publication History

Eingegangen: 03 March 1992

31 March 1992

Publication Date:
04 February 2018 (online)

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Zusammenfassung

In kortikalen Arealen, die einem epileptischen Fokus assoziiert sind, korreliert meist eine verminderte Benzodiazepin-Rezeptorbindung, darstellbar mit 123I- Iomazeml, mit einer Minderung des regionalen zerebralen Blutflusses. Anhand eines Fallbeispiels mit ausgeprägter Minderung der 123l-lomazenilbindung im epileptischen Fokus bei ungestörtem regionalen zerebralen Blutfluß wird illustriert und diskutiert, daß bei einer Minderanreicherung von 123I-Iomazenil im epileptischen Fokus eine Alteration des GABAergen Systems anzunehmen ist.

Summary

In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazeml, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.

Schlüsselwörter

Kortikale Dysplasie - Epilepsie - SPECT - Benzodiazepinrezeptoren

Key words

Cortical dysplasia - epilepsy - SPECT - benzodiazepine receptors
 

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