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Nuklearmedizin 1987; 26(03): 126-130
DOI: 10.1055/s-0038-1628875
Review Articles
Schattauer GmbH

Development of an Animal Model Using a Closed System to Study the Sensitivity of a Radiopharmaceutical for the Detection of Gastrointestinal Bleeding

A. Owunwanne
*   From the Departments of Nuclear Medicine and of Surgery
,
K. K. Mahajan
*   From the Departments of Nuclear Medicine and of Surgery
,
H. M. Abdel-Dayem
*   From the Departments of Nuclear Medicine and of Surgery
,
S. B. S. Ericksson
*   From the Departments of Nuclear Medicine and of Surgery
,
S. Sadek
*   From the Departments of Nuclear Medicine and of Surgery
,
T. Yacoub
*   From the Departments of Nuclear Medicine and of Surgery
,
M. Awdeh
*   From the Departments of Nuclear Medicine and of Surgery
› Author AffiliationsThis work was supported by Kuwait University grants MS 009 and MLN 018. Part of this work was presented at the European Nuclear Medicine Congress 1986, Goslar, Federal Republic of Germany. September 2-5, 1986 and the IV World Congress, World Federation of Nuclear Medicine and Biology, Buenos Aires, Argentina, November 2-7, 1986.
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Publication History

Received: 10 November 1986

in revised form: 03 March 1987

Publication Date:
04 February 2018 (online)

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An experimental animal model using a closed system to study the sensitivity of radiopharmaceuticals for the detection and localization of gastrointestinal (Gl) bleeding site in a sheep was developed. This model was validated with 99mTc-DTPA. Radioactivity as low as 85.47 ± 13.32 kBq in a volume of 2.1 ±0.14 ml at a bleeding rate of 0.07 ml/min was detected. Simulated intermittent bleeding experiments indicated that at 1 h after injection of 99mTc-DTPA there was still enough circulating radioactivity to bleed into the gut and that it was possible to perform repeat injection of 99mTc-DTPA as early as 2 h after the first injection.

Zusammenfassung

Ein experimentelles Tiermodell (geschlossenes System) wurde entwik-kelt, das die Sensitivität einzelner Radiopharmazeutika in der Entdeckung und Lokalisation gastrointestinaler Blutungen ermöglicht. Dieses Modell wurde am Schaf mit 99mTc-DTPA erprobt. Hiermit konnten Blutungsmengen von 0,07 ml/min (85,47 ± 13,32 kBq/2,1 ± 0,14 ml) entdeckt werden. Die Simulation einer intermittierenden Blutung ergab, daß eine Stunde nach der Injektion von 99mTc-DTPA ausreichende Radioaktivitätsmengen im Blut zirkulieren, um auch dann Blutungen nachzuweisen. Auch die Reinjektion des Tracers nach zwei Stunden erwies sich als brauchbarer Weg.

 

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