Myasthenia gravis

Zusammenfassung

Die erworbene Myasthenia gravis ist eine seltene autoimmunologische Erkrankung der neuromuskulären Signaltransduktion, die durch Autoantikörper gegen den nikotinischen Azetylcholinrezeptor an der muskulären Endplatte und in seltenen Fällen durch Antikörper gegen die muskelspezifische Rezeptor-Tyrosinkinase (MuSK) hervorgerufen wird. Diese Übersicht fasst den aktuellen Wissensstand zur Pathogenese, Diagnostik und Therapie der Myasthenia gravis zusammen.

Summary

Acquired myasthenia gravis is a rare autoimmune disease of the neuromuscular transmission, resulting from autoantibodies against the nicotinic acetylcholine receptor at the neuromuscular junction or, less frequently, against a muscle-specific receptor tyrosine kinase (MuSK). This review summarizes the current knowledge with respect to pathogenesis, diagnosis, and therapy of myasthenia gravis.

Schlüsselwörter

Myasthenia gravis - Autoantikörper - Azetylcholinrezeptor - Synapse

Keywords

Myasthenia gravis - autoantibodies - acetylcholine receptor - synapse

• Literatur

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