Schlaf & arterielle Hypertonie

Der Schlaf beeinflusst eine Vielzahl physiologischer Prozesse und die autonome Nervenfunktion. Auch Herzfrequenz und Blutdruck werden Schlafstadien-abhängig reguliert mit einem Absinken des systolischen und diastolischen Blutdrucks und der Herzfrequenz im Tiefschlaf. Ein fehlendes Absinken des Blutdrucks (Non-Dipping) oder gar ein Anstieg sind unabhängige Prädiktoren für das kardiovaskuläre Risiko.

Publication History

Article published online:
10 February 2018

• Literatur

• 1 Ben-Dov IZ, Kark JD, Ben-Ishay D. et al. Predictors of all-cause mortality in clinical ambulatory monitoring: unique aspects of blood pressure during sleep. Hypertension 2007; 49: 1235-1241.
• 2 Sega R, Facchetti R, Bombelli M. et al. Prognostic value of ambulatory and home blood pressure compared with office blood pressure in the general population: follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) Study. Circulation 2005; 111: 1777-1783.
• 3 Kearny PM, Whelton M, Reynolds K. et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217-223.
• 4 Gottlieb DJ, Redline S, Nieto FJ. et al. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep 2006; 29: 1009-1014.
• 5 Tochikubo O, Ikeda A, Miyajima E, Ishii M. Effects of insufficient sleep on blood pressure monitored by a new multibio-medical recorder. Hypertension 1996; 27: 1318-1324.
• 6 Pankow W, Nabe B, Lies A. et al. Influence of sleep apnea on 24-hour blood pressure. Chest 1997; 112: 1253-125.
• 7 Marin JM, Agusti A, Villar I. et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA 2012; 307: 2169-2176.
• 8 Calhoun DA, Jones D, Textor S. et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 2008; 51: 1403-1419.
• 9 He QY, Feng J, Zhang XL. et al. Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China. Chin Med J 2010; 123: 18-22.
• 10 Fava C, Dorigoni S, Dalle Vedove F. et al. Effect of continuous positive airway pressure (CPAP) on blood pressure in patients with obstructive sleep apnea/hypopnea. A systematic review and meta-analysis. Chest 2013; 26 13-1115
• 11 Lozano L, Tovar JL, Sampol G. et al. Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. J Hypertens 2010; 28: 2161-2168.
• 12 Martinez-Garcia MA, Capote F, Campos-Rodriguez F. et al. Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIP-ARCO randomized clinical trial. JAMA 2013; 310: 2407-2415.
• 13 White LH, Bradley TD. Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea. J Physiol 2013; 591: 1179-1193.
• 14 Friedman O, Bradley TD, Logan AG. Influence of lower body positive pressure on upper airway cross-sectional area in drug-resistant hypertension. Hypertension 2013; 61: 240-245.
• 15 Pratt-Ubunama MN, Nishizaka MK, Boedefeld RL. et al. Plasma aldosterone is related to severity of obstructive sleep apnea in patients with resistant hypertension. Chest 2007; 131: 453-459.
• 16 Pennestri MH, Montplaisir J, Combo R. et al. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 2007; 68: 1213-1218.
• 17 Calhoun DA, Harding SM. Sleep and hypertension. Chest 2010; 138: 434-443.
• 18 Vgontzas AN, Liao D, Bixler EO. et al. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep 2009; 32: 491-497.