Papillary Thyroid Carcinoma in a Toxic Adenoma

Summary

A patient with a well differentiated papillary carcinoma within a toxic adenoma is reported. Only a few similar cases have been recorded in the literature. A common origin of both lesions is suggested.

Es wird über ein gut differenziertes papilläres Schilddrüsenkarzinom in einem toxischen Adenom berichtet. Nur wenige gleichartige Fälle sind in der Literatur zu finden. Eine gemeinsame Genese beider Läsionen wird erwogen.

• References

• 1 Becker F. O, Economou P. G, Schwartz T. B. The occurrence of carcinoma in „hot“ thyroid nodules. Report of two cases. Ann. intern. Med 1963; 58: 877.
• 2 Dorta T, Lemarchand-Béraud T, Burri C. Ein Fall von Schilddrüsenkarzinom mit hyperfunktionierenden Metastasen. Schweiz, med. Wschr 1968; 98: 701.
• 3 Dunn J. T, Ray S. C. Changes in iodine metabolism and thyroglobulin structure in metastatic follicular carcinoma of the thyroid with hyperthyroidism. J. clin. Endocr 1973; 36: 1088.
• 4 Federman D. D. Hyperthyroidism due to functioning metastatic carcinoma of the thyroid. Medicine 1964; 43: 267.
• 5 Ferriman D, Hennebry T. M, Tassopoulos C. N. Quart. J. Med. N. S 1972; 41: 127.
• 6 Franssila K. Value of histologic classification of thyroid cancer. Acta path, microbiol. scand., section A, Suppl. 1971: 225.
• 7 Ghose M. K, Genuth S. M, Abellera R. M, Friedman S, Lidsky S. Functioning primary thyroid carcinoma and metastases producing hyperthyroidism. J. clin. Endocr 1971; 33: 639.
• 8 Goolden A. W. G. The effect of radiation on the thyroid gland. In Prunty F. T. G, Gardiner-Hill H. Modern trends in endocrinology —4. Butterworths, London: 1972: 250.
• 9 Guinet P, Tournaire J, Radi A. Hyperthyroïdie et cancer thyroïdien. Rev. franc, endocr., clin. nutr. metab 1972; 13: 199.
• 10 Hamburger J. I. Hyperthyroidism. Concept and controversy. Charles C; Thomas Publ., Springfield, III: 1972
• 11 Hamburger J. I. Solitary autonomously functioning thyroid lesions. Amer. J. Med 1975; 58: 740.
• 12 Hamilton C. R, Maloof F. Unusual types of hyperthyroidism. Medicine 1973; 52: 195.
• 13 Hintze G, Lamberg B.-A, Wahlberg P, Malm P. Radioiodine thyroid scanning as applied to thyroid problems in an endemic goitre region. Acta med. scand 1962; 171: 99.
• 14 Horst W, Rösier H, Schneider C, Labhart A. Three hundred six cases of toxic adenoma. J. nucl. Med 1967; 8: 515.
• 15 Höfer R. Toxic adenoma. Duodecim (Helsinki) 1971; 87: 1554.
• 16 Lamberg B.-A, Heinonen O. P, Viherkoski M, Aro A, Liewendahl K, Kvist G, Laitinen O, Knekt P. Diagnosis of hyperthyroidism. Acta endocr. (Kbh.). 1970. Suppl 146.
• 17 Lemarchand-Béraud T, Valenta L, Vannotti A. Biochemical differences between normal and cancerous thyroid tissues. In Hedinger C. E. (Ed.) Thyroid cancer. UICC Monograph series, Vol. 12. Springer-Verlag, Berlin—Heidelberg—New York: 1969: 205.
• 18 Liechty R. D, Graham M, Freemeyer P. Benign solitary thyroid nodules. Surg. Gyn. Obstet 1965; 121: 571.
• 19 Liewendahl K, Ruutu R, Lamberg B.-A. Diagnostic value of serum thyroxine and free thyroxine and free thyroxine index. Acta med. scand 1973; 194: 341.
• 20 Ljunggrén J.-G, Olin P, Jereb B. On the biosynthesis of thyroglobulin in thyroid carcinomas. In Fellinger K, Höfer R. (Eds.) Further advances in thyroid research. Verlag Wiener Med. Akad. 1971: 1221.
• 21 McKenzie J. M. The bioassay of thyrotropin in serum. Endocrinology 1958; 63: 372.
• 22 McLaughlin R. P, Scholz D. A, McConahey W. M, Childs D. S. Metastatic thyroid carcinoma with hyperthyroidism: two cases with functioning metastatic follicular thyroid carcinoma. Mayo Clin. Proc 1970; 45: 328.
• 23 Malamos B, Koutras D. A, Fringeli D, Tassopoulos C. N. Toxic adenoma of the thyroid. Horm. Metab. Res 1969; 1: 19.
• 24 Meadows P. M. Scintillation scanning in the management of the clinically single thyroid nodule. J. Amer, med. Ass 1961; 177: 229.
• 25 Meier D. A, Hamburger J. I. An autonomously functioning thyroid nodule, cancer, and prior radiation. Arch. Surg 1971; 103: 759.
• 26 Molnar G. D, Childs D. S, Woolner L. B. Histologic evidence of malignancy in a thyroid gland bearing a “hot“ nodule. J. clin. Endoer 1958; 18: 1132.
• 27 Nĕmec J, Bednár J, Váňa S, Soumar J, Soutorová M. Metastatizing thyroid carcinoma: Development of thyrotoxic crisis and behaviour of iodinated compounds in the blood after treatment with radioactive iodine of functionally active metastases of the lungs. Nucl.-Med 1969; 8: 275.
• 28 Oberdisse K, Klein E. Die Krankheiten der Schilddrüse. Georg Thieme Verlag, Stuttgart. 1967
• 29 Refetoff S, Harrison J, Karanfilski B. T, Kaplan E. L, de Groot L. J, Bekerman C. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. New Engl. J. Med 1975; 292: 171.
• 30 Riccabona G. Die endemische Struma. Urban & Schwarzenberg, München-Berlin-Wien: 1972
• 31 Studer H, Veraguth P, Wyss F. Thyreotoxikose infolge Solitärmetastase eines Schilddrüsenkarzinoms. Schweiz, med. Wschr 1962; 87: 2676.
• 32 Sussman L, Librik L, Clayton G. W. Hyperthyroidism attributable to a hyperfunctioning thyroid carcinoma. Pediatrics 1968; 72: 208.
• 33 Thomas-Morvan C, Nataf B, Tubiana M. Thyroid proteins and hormone synthesis in human thyroid cancer. Acta endocr. (Kbh.) 1974; 76: 651.
• 34 Valenta L, Lemarchand-Béraud T, Nĕmec J, Griessen M, Bednář J. Metastatic thyroid carcinoma provoking hyperthyroidism, with elevated circulating thyrostimulators. Amer. J. Med 1970; 48: 72.
• 35 Valenta L, Lissitsky S, Aquaron R. Thyroglobulin-iodine in thyroid tumours. J. clin. Endocr 1968; 28: 437.
• 36 Valenta L, Kyncl F, Niederle B, Jirousek L. Soluble proteins in thyroid neoplasia. J. clin. Endocr 1968; 28: 442.