Nuklearmedizin 1986; 25(06): 245-248
DOI: 10.1055/s-0038-1624352
Originalarbeiten — Original Articles
Schattauer GmbH

Limitations in Localising and Killing Tumours Using Radiolabelled Antibodies[*]

A.R. Bradwell
1   From the Immuno Diagnostic Research Laboratory, Department of Immunology, The Medical School, University of Birmingham, Birmingham, United Kingdom
,
A.T.M. Vaughan
1   From the Immuno Diagnostic Research Laboratory, Department of Immunology, The Medical School, University of Birmingham, Birmingham, United Kingdom
,
P.W. Dykes
*   From the Immuno Diagnostic Research Laboratory, Department of Immunology, The Medical School, University of Birmingham, and The General Hospital, Birmingham, United Kingdom
› Author Affiliations
We would like to thank the Cancer Research Campaign for their support of this work. The figures have been reproduced with the kind permission of Pitman Publishing Ltd. (Figs. 1-3) and the Lancet (Fig. 4).
Further Information

Publication History

Received: 30 June 1986

Publication Date:
20 January 2018 (online)

Radiolabelled antibodies against tumours are being studied intensely for their use in tumour detection and tumour destruction. Although a host of different tumour types can be localised, results at present are no better than other scanning techniques. In addition no tumour has been eradicated using labelled antibodies. Dramatic improvements will depend upon a fuller understanding of tumour cell biology and optimising all the parameters involved.

Zusammenfassung

Radioaktiv markierte Antikörper gegen Tumore wurden bezüglich ihrer Anwendung zur Tumorortung und Zerstörung intensiv untersucht. Obwohl eine große Anzahl unterschiedlicher Tumore lokalisiert werden kann, sind die Resultate gegenwärtig nicht besser als die mit anderen Scan- Techniken. Außerdem konnte kein Tumor durch Anwendung markierter Antikörper ausgerottet werden. Eine dramatische Verbesserung wird von einem vollständigeren Verständnis der Tumorzellbiologie und einer Optimierung aller einbezogenen Parameter abhängen.

* Presented at the Symposion on “Monoclonal Antibodies in Nuclear Medicine” in Freiburg i-Br., May 1-3, 1986.


 
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