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Nuklearmedizin 1986; 25(01): 28-30
DOI: 10.1055/s-0038-1624315
Originalarbeiten - Original Articles
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Tumor Localization and Biodistribution of 99mTc-Muramylpolypeptide(MPP) in the Rat[*]

Tumoranreicherung und Bioverteilung von 99m Tc-MuramylpoIypeptid (MPP) in der Ratte
C. Schümichen
1   From the Department of Nuclear Medicine (Director : Prof. Dr. G. Hoffmann), Albert-Ludwigs-University of Freiburg, Federal Republic of Germany
,
H. Weiß
1   From the Department of Nuclear Medicine (Director : Prof. Dr. G. Hoffmann), Albert-Ludwigs-University of Freiburg, Federal Republic of Germany
› Author AffiliationsThe authors wish to thank Dr. W. Ehrenfeld from Jomol Pharma, Alling/Regensburg for supplying the material, Prof. Dr. K. Görttler and H. Lörke from the DKFZ, Heidelberg for supplying the tumor and Dr. U. Zimmermann, Pathologisch-anatomisches Institut, Regensburg, for his microscopical work.
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Publication History

Received: 07 January 1986

Publication Date:
12 January 2018 (online)

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Summary

Muramylpolypeptide, extracted from Nocardia opaca bacteria and originally designed for immunotherapy of malignant tumors, proved to localize in malignant tumors, when labeled with 99m Tc. In the tumor-bearing rat 99m Tc-muramylpolypeptide (MPP) showed a fast turnover and optimum tumor to soft tissue ratios were obtained as early as between 30-60 min after application. The uptake mechanism in malignant tumors remains uncertain.

Zusammenfassung

Muramylpolypeptid, aus Nocardia-opaca-Bakterien extrahiert und ursprünglich für die Immuntherapie maligner Tumoren entwickelt, reicherte sich nach Markierung mit 99m Tc in malignen Tumoren an. In der tumortragenden Ratte zeigte 99m Tc-Muramylpolypeptid (MPP) einen schnellen Umsatz, so daß optimale Tumor- zu Weichteil- Ratios bereits 30-60 min nach Applikation erreicht wurden. Der Anreicherungsmechanismus in malignen Tumoren bleibt unklar.

* Prof. Dr. W. Gerok dedicated on his 60th birthday


 

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