1-123-Iodo-α-methyl tyrosine SPECT in non-parenchymal brain tumours

P. Matheja; M. Weckesser; Ch. Rickert; Ch. Franzius; St. Palkovic; B. Riemann; O. Schober

doi:10.1055/s-0038-1623895

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 2002; 41(04): 191-196
DOI: 10.1055/s-0038-1623895

Original Article

Schattauer GmbH

1-123-Iodo-α-methyl tyrosine SPECT in non-parenchymal brain tumours

I-123-Iod-α-methyl-tyrosinSPECT nicht-parenchymaler Hirntumoren

Authors

P. Matheja

¹Departments of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
M. Weckesser

¹Departments of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
Ch. Rickert

³Institute of Neuropathology (Head: Prof. Dr. W. Paulus), University Hospital Münster, Germany
Ch. Franzius

¹Departments of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
St. Palkovic

²Neurosurgery (Head: Prof. Dr. H. Wassmann)
B. Riemann

¹Departments of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)
O. Schober

¹Departments of Nuclear Medicine (Head: Prof. Dr. Dr. O. Schober)

Abstract

Summary

Purpose: Scintigraphy using I-123-iodo-α-methyl tyrosine (IMT) is useful in the preoperative characterization of gliomas, in detecting recurrent glioma and in the biological re-evaluation of residual or recurrent tumours. A systematic evaluation of non-parenchymal brain tumours has not yet been performed. The aim of the present study was to evaluate IMT SPECT in the management of intracerebral metastases and lymphomas. Patients and methods: IMT uptake was analyzed in 31 patients with 28 metastases of extracerebral solid tumours and 7 cerebral lymphomas. Histology revealed high grade lymphomas, melanomas, and carcinomas of the following origin: lung, unknown primary, breast, colon, renal cell, ovary, vagina, frontal sinus. IMT uptake was quantified as ratio between maximal tumour accumulation and average uptake in the contralateral hemisphere. Results: All tumours except two renal cell and one small cell lung carcinoma metastases accumulated IMT (91%). The highest IMT uptake was found in a metastasis of lung carcinoma. IMT uptake was highly variable and was similar in primary and in recurrent tumours. Conclusion: Significant accumulation of IMT is seen in the majority of tumours, so that this technique might be helpful for the management of cerebral metastases and lymphomas.

Zusammenfassung

Ziel: Die Szintigraphie mit I-123-Iod-α-methyl-tyrosin (IMT) ist bei der präoperativen Charakterisierung von Gliomen, der Erkennung von Gliomrezidiven und bei der biologischen Evaluation residueller oder rezidivierender Tumoren nützlich. Eine systematische Analyse der nichtparenchymatösen Hirntumoren wurde bisher nicht durchgeführt. Das Ziel dieser Studie war es, die IMTSPECT beim Management intrazerebraler Metastasen und Lymphome zu analysieren. Patienten und Methoden: Die IMT-Aufnahme wurde bei 31 Patienten mit 28 Metastasen solider Tumoren und 7 zerebralen Lymphomen untersucht. Die histologische Untersuchung ergab hochgradig maligne Lymphome, Melanome und Karzinome folgender Herkunft: Lunge, unbekannter Primärtumor, Mamma, Kolon, Niere, Ovar, Vagina und Sinus frontalis. Die IMT-Aufnahme wurde als Quotient zwischen maximaler Tumoranreicherung und durchschnittlicher Aufnahme der kontralateralen Hemisphäre quantifiziert. Ergebnisse: Alle Tumoren mit Ausnahme zweier Nierenzellkarzinommetastasen und einer Metastase eines kleinzelligen Bronchialkarzinoms reicherten IMT an (91%). Die höchste Aufnahme wurde in einer Bronchialkarzinommetastase gefunden. Die IMT-Aufnahme war sehr variabel. Zwischen Primärtumoren und Rezidiven war sie vergleichbar. Schlussfolgerung: Die Tumoren reichen signifikant IMT an, sodass diese Methode möglicherweise beim Management zerebraler Metastasen und Lymphome hilfreich ist.

Keywords

Brain tumour - SPECT - I-123-iodo-α-methyl tyrosine - metastasis - lymphoma

Schlüsselwörter

Hirntumor - SPECT - I-123-Iod-α-methyl-tyrosin - Metastase - Lymphom

Full Text

References

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