Nuklearmedizin 1979; 18(06): 297-299
DOI: 10.1055/s-0037-1620920
Originalarbeiten – Original Articles
Schattauer GmbH

Conversion of 3H-Testosterone to Dihydrotestosterone in Human Hypertrophic Prostatic Tissue

Umwandlung von 3H-Testosteron in Dihydrotestosteron durch hypertrophisches Prostatagewebe des Menschen
B. Baranowska
1   From the Clinic of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland
,
S. Zgliczynski
1   From the Clinic of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland
› Author Affiliations
Further Information

Publication History

Received: 10 October 1979

Publication Date:
09 January 2018 (online)

Summary

The aim of the study was to develop a simple method for the determination of the conversion of testosterone to 5α-dihydrotestosterone (5α-DHT) after incubation of human hypertrophic prostatic tissue with 3H-testosterone. The mean conversion rate of 3H-testosterone to 5α-DHT in hypertrophic prostatic tissue was found to be higher than in normal and carcinomatous tissue. The results indicate that androgen metabolism in the hypertrophic prostatic gland is enhanced.

Zusammenfassung

Das Ziel der Untersuchung war die Entwicklung einer einfachen Methode der Bestimmung der Umwandlung von Testosteron in 5α-Dihydrotestosteron (5α-DHT) nach der Inkubation menschlichen hypertrophischen Prostatagewebes mit 3H-Testosteron. Der durchschnittliche Konversionsindex des 3H-Testosterons in 5α-DHT in hypertrophischem Prostatagewebe war höher als in normalem oder karzinomatösem Gewebe. Die Ergebnisse weisen darauf hin, daß der Androgenstoffwechsel in der hypertrophischen Prostatadrüse erhöht ist.

 
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